CDK5R1 and CHN1

Number of citations of the paper that reports this interaction (PubMedID 15013773)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CDK5R1	CHN1
Description		cyclin dependent kinase 5 regulatory subunit 1	chimerin 1
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Ephrin Receptor Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Signal Transduction Nervous System Development Motor Neuron Axon Guidance Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction
Pathways		CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes	CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases			Duane retraction syndrome
GWAS			Post bronchodilator FEV1 ( 26634245)
Interacting Genes		35 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1	16 interacting genes: ACVR1 ADORA2A ANKK1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 HTR6 MAPK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1
Entrez ID		8851	1123
HPRD ID		04586	00319
Ensembl ID		ENSG00000176749	ENSG00000128656
Uniprot IDs		Q15078 Q8N619	P15882
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS	2OSA 3CXL
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth	Protein Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cell Projection Organization Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Schwann Cell Development Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Targeting To Membrane Motor Neuron Axon Guidance Dendrite Protein Kinase 5 Complex Cerebral Cortex Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Targeting To Membrane Positive Regulation Of Apoptotic Process Cell Migration Response To Growth Factor Positive Regulation Of Programmed Cell Death Positive Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization ErbB-3 Class Receptor Binding Telencephalon Cell Migration Growth Factor Binding Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Forebrain Cell Migration Trans-synaptic Signaling SMAD Binding Synaptic Signaling Dendrite Morphogenesis Neuronal Cell Body Neuron Differentiation Regulation Of Protein Modification Process Positive Regulation Of Supramolecular Fiber Organization Activin Receptor Complex Activin Receptor Activity, Type I Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway
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