SYNGAP1 and GRIN1

Number of citations of the paper that reports this interaction (PubMedID 10862698)
0

Data Source:
HPRD (in vivo)

		SYNGAP1	GRIN1
Description		synaptic Ras GTPase activating protein 1	glutamate ionotropic receptor NMDA type subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Dendritic Shaft Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Monoatomic Ion Channel Complex Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Neurotransmitter Receptor Complex
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Sodium Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Glycine-gated Cation Channel Activity
	Biological Process	Ras Protein Signal Transduction Pattern Specification Process Axonogenesis Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Modulation Of Chemical Synaptic Transmission Neuron Apoptotic Process Maintenance Of Postsynaptic Specialization Structure Regulation Of Intracellular Signal Transduction	Monoatomic Ion Transport Monoatomic Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Response To Glycine Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Regulation of RAS by GAPs	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		32 interacting genes: CAMK2A CRK DLG3 DLG4 DLGAP4 DSCAM EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR LCOR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX	58 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 NR1H4 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		8831	2902
HPRD ID		16018	15926
Ensembl ID		ENSG00000197283	ENSG00000176884
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	Q05586 Q59GW0 Q5VSF9
PDB IDs			2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 7EU8 7YFF 7YFL 7YFM 7YFO 7YFR 8E92 8E93 8E94 8E96 8E97 8E98 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8UUE 8VUL 8VUN 8VUQ 8VUR 8VUS 8VUT 8VUU 8VUV 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C 9GIB 9GIC 9GID 9GIE 9GIF 9GIG 9GJ1
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Glutamate Binding Postsynaptic Density Positive Regulation Of Synaptic Transmission, Glutamatergic NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Dendritic Spine Development Neuron Projection Glutamate Receptor Signaling Pathway Regulation Of Nervous System Process Protein Autophosphorylation Synapse Developmental Process Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Binding Chemical Synaptic Transmission Ionotropic Glutamate Receptor Binding Modulation Of Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Trans-synaptic Signaling AMPA Glutamate Receptor Clustering Protein Phosphorylation Kinase Binding Synaptic Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Postsynaptic Membrane Phosphorylation Synaptic Transmission, Glutamatergic Neuron Spine Protein Modification Process Receptor Clustering Neuron Projection Morphogenesis Long-term Synaptic Potentiation Signaling Regulation Of Membrane Potential Social Behavior Glycine Binding	Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Biological Quality Regulation Of Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Synaptic Transmission Chemical Synaptic Transmission Regulation Of Cellular Component Organization Long-term Synaptic Potentiation Neuron Projection Synapse Signaling Postsynaptic Density Membrane Cell Communication Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Signaling Regulation Of Transport Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Anatomical Structure Morphogenesis Regulation Of Synapse Organization Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Signal Transduction Plasma Membrane Postsynaptic Density Regulation Of Metal Ion Transport Regulation Of Cellular Localization Learning Or Memory Cell Projection Protein Kinase Binding Regulation Of Apoptotic Process Cell Junction Organization NMDA Glutamate Receptor Activity Regulation Of Calcium Ion Transport Dendrite Ligand-gated Ion Channel Signaling Pathway Regulation Of Protein Localization Developmental Process Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cognition
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