SYNGAP1 and CAMK2A

Number of citations of the paper that reports this interaction (PMID 15312654)
61

Data Source:
HPRD (in vitro, in vivo)

		SYNGAP1	CAMK2A
Gene Name		synaptic Ras GTPase activating protein 1	calcium/calmodulin-dependent protein kinase II alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Dendritic Shaft	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Rab GTPase Activator Activity Ras GTPase Activator Activity SH3 Domain Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways			Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: CAMK2A DLG3 DLG4 DLGAP4 GRIN1 GRIN2B GRIN2D KDR MPDZ PDGFRB TRIP6 ULK1 ULK2	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		8831	815
HPRD ID		16018	06532
Ensembl ID		ENSG00000197283	ENSG00000070808
Uniprot IDs		Q96PV0	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Cell-cell Signaling Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Signaling Startle Response Cell Communication Neuron Projection Morphogenesis Neuromuscular Process Cell Development Cell Morphogenesis Involved In Differentiation Response To External Stimulus Locomotion Regulation Of Synaptic Plasticity Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Regulation Of Neuronal Synaptic Plasticity Movement Of Cell Or Subcellular Component Glutamate Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Neuron Development Neuron-neuron Synaptic Transmission Receptor Localization To Synapse Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Anatomical Structure Morphogenesis Cell Morphogenesis Chemotaxis Neuron Differentiation Cell Projection Organization Regulation Of Synaptic Transmission Phosphorylation Membrane Depolarization Cellular Response To Stimulus Protein Localization To Synapse Axon Guidance Learning System Development Regulation Of Signaling Suckling Behavior Nervous System Development Regulation Of Axonogenesis Single-organism Behavior Generation Of Neurons	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?		asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect scn8a segregating seizures suited synj1 translating unrevealing wes	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect scn8a segregating seizures suited synj1 unrevealing wes	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene tta
Tagcloud (Intersection) ?		translating