BCAS3 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BCAS3	PALB2
Description		BCAS3 microtubule associated cell migration factor	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Euchromatin Nucleus Cytoplasm Cytoskeleton Cytoplasmic Microtubule Cell Leading Edge Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex
	Molecular Function	Chromatin Binding Protein Binding Acetyltransferase Activator Activity Nuclear Receptor Binding Histone Acetyltransferase Binding Phosphatidylinositol Binding Histone Binding Beta-tubulin Binding	DNA Binding Protein Binding
	Biological Process	Angiogenesis Autophagy Cell-cell Signaling Positive Regulation Of Endothelial Cell Migration Regulation Of Actin Cytoskeleton Organization Response To Starvation Positive Regulation Of Catalytic Activity Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estrogen Stimulus	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Drugs
Diseases			Fanconi anemia
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Alzheimer's disease (cognitive decline) ( 23535033) Blood urea nitrogen levels ( 31152163 29403010) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Calcium levels ( 29403010) Chronic kidney disease ( 20383146 31152163) Coronary artery disease ( 33020668 29212778 26343387 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31451708 29779033 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 25967671 32238385) Gout (combined type) ( 32238385) Heel bone mineral density ( 28869591 30598549) Height ( 18391951) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immune reponse to smallpox (secreted IL-2) ( 22610502) Intraocular pressure ( 31959993 29785010 30054594 29617998) Lung function (FEV1/FVC) ( 30804560) Macular thickness ( 30535121) Medial orbital frontal cortex volume ( 31530798) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Optic cup area ( 28073927 25631615 31798171) Optic disc size ( 31809533) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum creatinine levels ( 29779033) Serum uric acid levels ( 29403010 30993211 32514006) Systolic blood pressure ( 30578418 30224653) Thyroid stimulating hormone levels ( 32769997 30367059) Urate levels ( 31985003 31578528 23263486) Urolithiasis ( 30975718) Vertical cup-disc ratio ( 20548946) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitamin C levels ( 33203707) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 17554300)
Interacting Genes		23 interacting genes: ATM BAG4 CCND1 CDC23 CTBP1 CTBP2 DDB1 FBXW7 H3C1 KRAS MTDH PALB2 PELP1 PHB1 PLEKHF2 PTPN1 SMAD4 STK11 TGFB1 TP53 TSG101 XRCC3 ZDHHC17	31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3
Entrez ID		54828	79728
HPRD ID		06313	07966
Ensembl ID		ENSG00000141376	ENSG00000083093
Uniprot IDs		Q05D99 Q9H6U6	A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2
PDB IDs			2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Response To Radiation Cellular Response To Radiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Neuron Apoptotic Process Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Ionizing Radiation Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Repressor Complex Regulation Of ERK1 And ERK2 Cascade Response To UV Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Growth Regulation Of Cell Cycle Process Response To Light Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Cellular Response To UV Response To X-ray Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Developmental Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Regulation Of Cell Growth Cellular Response To Light Stimulus	Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?