UBE2S and CDC20

Number of citations of the paper that reports this interaction (PMID 25306923)
0

Data Source:
BioGRID (pull down, pull down)

		UBE2S	CDC20
Gene Name		ubiquitin-conjugating enzyme E2S	cell division cycle 20
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Gene Ontology Annotations	Cellular Component	Anaphase-promoting Complex Cytoplasm	Spindle Pole Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Protein C-terminus Binding Enzyme Binding
	Biological Process	Cellular Protein Modification Process Exit From Mitosis Free Ubiquitin Chain Polymerization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Activation Of Anaphase-promoting Complex Activity Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Mitotic Cell Cycle Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiosis Regulation Of Dendrite Development Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synapse Maturation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Phosphorylation of Emi1 Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD FZR1 OTUB1 OTUD7B RBCK1 STAMBP UBA1 UBA6 UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1	37 interactors: ANAPC1 ANAPC10 ANAPC2 ANAPC5 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CDC16 CDC27 CDC6 CDR2 CDT1 FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 MAD2L1 MAD2L2 PIM1 PLK1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 UBE2C UBE2S
Entrez ID		27338	991
HPRD ID		15603	04686
Ensembl ID		ENSG00000108106	ENSG00000117399
Uniprot IDs		Q16763	Q12834
PDB IDs		1ZDN	4GGA 4GGC 4GGD
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein K11-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Spindle Assembly Checkpoint Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Chromosome Segregation Protein Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Spindle Checkpoint Negative Regulation Of Chromosome Organization Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Modification By Small Protein Removal Protein Ubiquitination Negative Regulation Of Cellular Protein Catabolic Process	Regulation Of Cell Cycle Mitotic Nuclear Division Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Regulation Of Protein Ubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Chromosome Organization Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?		arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?