UBE2S and CYLD

Number of citations of the paper that reports this interaction (PMID 20622874)
46

Data Source:
BioGRID (enzymatic study)

		UBE2S	CYLD
Gene Name		ubiquitin-conjugating enzyme E2S	cylindromatosis (turban tumor syndrome)
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Gene Ontology Annotations	Cellular Component	Anaphase-promoting Complex Cytoplasm	Nucleoplasm Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Structural Constituent Of Ribosome Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding
	Biological Process	Cellular Protein Modification Process Exit From Mitosis Free Ubiquitin Chain Polymerization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Activation Of Anaphase-promoting Complex Activity Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Cytoplasmic Translation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Innate Immune Response Negative Regulation Of T Cell Differentiation Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Cilium Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Crohn's disease ( 22412388) Leprosy ( 22019778)
Protein-Protein Interactions		29 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD FZR1 OTUB1 OTUD7B RBCK1 STAMBP UBA1 UBA6 UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1	15 interactors: AKT1 AURKB DDX58 HDAC6 IKBKG ITCH MAPRE1 OPTN PPP2R4 TRAF2 TRAF6 TRAF7 TRAIP TUBA1A UBE2S
Entrez ID		27338	1540
HPRD ID		15603	05427
Ensembl ID		ENSG00000108106	ENSG00000083799
Uniprot IDs		Q16763	Q9NQC7
PDB IDs		1ZDN	1IXD 1WHL 1WHM 2VHF
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein K11-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Spindle Assembly Checkpoint Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Chromosome Segregation Protein Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Spindle Checkpoint Negative Regulation Of Chromosome Organization Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Modification By Small Protein Removal Protein Ubiquitination Negative Regulation Of Cellular Protein Catabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Polyubiquitination Cell Death Death Regulation Of Cell Death Positive Regulation Of Innate Immune Response Mitotic Cell Cycle Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Catabolic Process Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death NIK/NF-kappaB Signaling Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of JNK Cascade Cellular Protein Modification Process Protein K29-linked Ubiquitination Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Localization Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Innate Immune Response Intracellular Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna	181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate
Tagcloud (Difference) ?		arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna	181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate
Tagcloud (Intersection) ?