Wiki-Pi
About
Search
People
Updates
Search
PIK3R1 and ITSN1
Number of citations of the paper that reports this interaction (PubMedID
35914814
)
83
Data Source:
BioGRID
(two hybrid)
PIK3R1
ITSN1
Description
phosphoinositide-3-kinase regulatory subunit 1
intersectin 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Nucleus
Nuclear Envelope
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Endomembrane System
Membrane
Lamellipodium
Cytoplasmic Vesicle
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Synapse
Recycling Endosome
Apical Dendrite
Intracellular Vesicle
Postsynaptic Endocytic Zone
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
GTPase Activator Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Kinase Regulator Activity
Kinase Activator Activity
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Phosphatidylinositol Kinase Activity
Enzyme-substrate Adaptor Activity
Phosphatidylinositol 3-kinase Activator Activity
Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Molecular Adaptor Activity
Proline-rich Region Binding
Biological Process
Intracellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Positive Regulation Of Leukocyte Migration
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Immune Response
Negative Regulation Of Cell Adhesion
Signal Transduction
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Protein Transport
Cytokine-mediated Signaling Pathway
B Cell Differentiation
T Cell Differentiation
Osteoclast Differentiation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Regulation Of Toll-like Receptor 4 Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Interleukin-18-mediated Signaling Pathway
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of D-glucose Import
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
T Follicular Helper Cell Differentiation
Myeloid Leukocyte Migration
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Localization To Plasma Membrane
Exocytosis
Endocytosis
Intracellular Protein Localization
Regulation Of Cell Communication
Protein Transport
Endosomal Transport
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Growth Hormone Secretion
Positive Regulation Of Dendritic Spine Development
Regulation Of Postsynapse Organization
Clathrin-dependent Synaptic Vesicle Endocytosis
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Positive Regulation Of Caveolin-mediated Endocytosis
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK in cancer
Signaling by LTK
Co-stimulation by ICOS
NRAGE signals death through JNK
EPHB-mediated forward signaling
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
CDC42 GTPase cycle
RHOQ GTPase cycle
RHOG GTPase cycle
Drugs
SF1126
Enzastaurin
Wortmannin
Diseases
GWAS
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Appendicular lean mass (
33097823
)
Basal cell carcinoma (
33549134
)
Birth weight (
31043758
)
Body fat percentage and HDL-C (pairwise) (
33619380
)
Bone mineral density (hip) (
26911590
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
30604766
31152163
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Leg fat mass (lean adjusted) (
32719433
)
Leg fat mass and leg lean mass (pleiotropy) (
32719433
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
32203549
29083408
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Bitter non-alcoholic beverage consumption (
31046077
)
Educational attainment (
25201988
)
Height (
31562340
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
QT interval (
29213071
)
Red blood cell count (
32888494
)
Red cell distribution width (
27863252
32888494
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
180 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CIP2A
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FBXO21
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NLRP6
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTEN
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNK2
TNS4
TOM1L1
TRAT1
TRIM25
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
140 interacting genes:
AGFG1
AGFG2
AJUBA
ANKRD36
ANKRD54
ARF6
ARFIP2
ARHGAP31
ASAP2
BECN1
BFSP1
BRCC3
BRWD3
CCDC24
CCNO
CDC42
CEP85L
CLIP2
CLTC
COG4
CSNK2B
CYTH1
CYTH3
DAB1
DAB2
DES
DISC1
DLGAP1
DNAI7
DNAJA2
DNM1
DNM2
DST
DYNC1H1
EEF1A1
EPHB2
EPN2
EPS15
EXOC1
FCHO1
FCHO2
FCHSD2
FNBP1
FNBP4
GAREM2
GCC1
GFAP
GNPTG
GOLGA5
HIP1
HNRNPK
HRAS
IFT74
ITSN2
KHDRBS1
KIF16B
KIF5A
KIF5C
KRT222
LMO3
LMO4
MAP3K20
MAPK6
MAPK8IP2
MED4
MRPL20
MTUS2
MYH14
NASP
NEFL
NEFM
NEMF
PACSIN3
PDCD6IP
PDE2A
PDZD8
PFDN5
PICALM
PIK3AP1
PIK3C2B
PIK3R1
PLK1
PPFIA2
PPL
PREX1
PRRG4
RAB11FIP2
RAB5A
RABEP1
RAI14
RALBP1
REPS1
REPS2
RIN1
RNF40
RPS6KA5
RRBP1
SCAI
SCAMP1
SCOC
SF3B4
SH3GL2
SHANK3
SIAH1
SMARCC2
SMC1A
SNAP23
SNAP25
SNRNP70
SNX5
SNX6
SOS1
SOS2
SPDL1
SPECC1
SPRY2
SPTAN1
SPTBN1
STON2
SYNC
SYNE1
SYNJ1
SYNJ2
TK1
TRAF3IP1
TRIM5
TRIM8
TRPM7
TSG101
TTC27
UBC
UBE2K
UNC119
VLDLR
WASL
WBP11
WHAMM
ZFC3H1
ZFPM2
ZMYM5
Entrez ID
5295
6453
HPRD ID
01381
03898
Ensembl ID
ENSG00000145675
ENSG00000205726
Uniprot IDs
A0A2X0SFG1
P27986
A7XZY7
F8W7U0
Q15811
Q6PD56
PDB IDs
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
7CIO
7LM2
7LQ1
7MYN
7MYO
7PG5
7PG6
7RNS
7TZ7
8AM0
8DCP
8DCX
8DD4
8DD8
8GUB
8H36
8H37
8ILR
8ILS
8ILV
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8V8H
8V8I
8V8J
8V8U
8V8V
8W9A
8W9B
1KI1
2KGR
2KHN
3FIA
3QBV
4IIM
5HZI
5HZJ
5HZK
6GBU
6H5T
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Regulation Of Signal Transduction
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Protein Kinase Activity
Regulation Of Immune Response
Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphorylation
Immune Response-regulating Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Protein Phosphorylation
Receptor Complex
Positive Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune Response
Cell Migration
Cytokine-mediated Signaling Pathway
Protein Autophosphorylation
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Migration
Activation Of Immune Response
Endocytosis
Vesicle-mediated Transport
Import Into Cell
Cytoplasm
Cytosol
Establishment Of Localization In Cell
Clathrin-coated Pit
Clathrin Coat Assembly
Cytoskeleton Organization
Organelle Organization
Cytoskeleton
Regulation Of Cellular Component Organization
Receptor-mediated Endocytosis
Organelle Localization
Membrane Organization
Cellular Component Assembly
Clathrin-coated Vesicle
Protein Transport
Clathrin-dependent Endocytosis
Intermediate Filament-based Process
Cellular Localization
Establishment Of Organelle Localization
Intracellular Transport
Negative Regulation Of Cellular Component Organization
Synaptic Vesicle Endocytosis
Establishment Of Protein Localization
Regulation Of Protein Localization To Cell Periphery
Presynaptic Endocytosis
Vesicle-mediated Transport In Synapse
Intermediate Filament Cytoskeleton Organization
Intracellular Protein Localization
Protein-containing Complex Assembly
Clathrin Coat Of Coated Pit
Intermediate Filament Cytoskeleton
Protein-containing Complex Organization
Structural Constituent Of Cytoskeleton
Post-Golgi Vesicle-mediated Transport
Glutamatergic Synapse
Microtubule Binding
Establishment Of Vesicle Localization
Endosomal Transport
Cell Cortex
Cytoplasmic Vesicle
Golgi Vesicle Transport
Regulation Of Protein Localization To Plasma Membrane
Vesicle Localization
Cytoskeleton-dependent Intracellular Transport
Cell Projection Organization
Mitotic Cytokinesis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?