PIK3R1 and RAC1

  • Number of citations of the paper that reports this interaction (PMID 7629060)
  • 95
  • Data Source:
  • HPRD (in vitro)

PIK3R1

RAC1

Gene Name phosphoinositide-3-kinase, regulatory subunit 1 (alpha) ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
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Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease biomarkers ( 23419831)
  • Menarche (age at onset) ( 23599027)
Protein-Protein Interactions 149 interactors: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGFR EPHA2 EPOR ERAS ERBB2 ERBB3 ESR1 EZR FASLG FCGR2A FES FGFR1 FYN GAB1 GAB2 GAB3 GHR GRB2 GSK3B GSPT1 GTF2H1 HCK HCST HDAC1 HGS HOXA1 HRAS HTT IFNAR1 IGF1R IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KHDRBS1 KIT LAT LCK LCP2 MAPK8 MET MME MST1R NFKBIA NTRK1 NTRK2 NUP85 PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PSEN1 PSMB5 PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SRC SSTR2 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TOM1L1 TRAT1 TSHR TTR TUB TUBA1B TUBG1 TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG 144 interactors: ACTA1 ACTB AKT1 ARFIP2 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF2 ARHGEF25 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT CNTNAP1 COG5 COX3 CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DOCK1 DOCK2 DOCK8 DVL1 DVL2 EIF2AK2 FHOD1 FLNA FMNL1 GRN HACD3 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KALRN KPNA4 KPNA6 KRT40 KTN1 LATS1 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2L MCM3AP METAP2 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 OCRL OPHN1 PAK1 PAK2 PAK3 PAK7 PARD6A PARD6B PARD6G PARK2 PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG2 PLXNB1 PPP2R2B PRKCA PRKCD PRKCI PRMT6 PTK2 RALBP1 RAP1GDS1 RASGRF1 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 STAT1 STAT3 STAU1 SUMO2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1
Entrez ID 5295 5879
HPRD ID 01381 03627
Ensembl ID ENSG00000145675 ENSG00000136238
Uniprot IDs P27986 A4D2P0 A4D2P1 P63000
PDB IDs 1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
16q  1q  affymetrix  classic  clustering  clusters  cytoskeleton  distinguished  epithelium  fresh  frozen  golm1  gpr137b  hierarchical  ilc  lcis  lobular  mastectomy  microarrays  microdissected  obligate  personalize  precursor  prophylactic  supervised  transcriptomic  triplets  u133a  unsupervised 
3t3  activate  bind  chimeric  cytoskeletal  dispensable  effector  effectors  interrelationship  jnk  jun  lamellipodia  lamellipodium  mediate  nh2  nih  p65  pak  ras  rho  rhoa  ruffling  srf  stimulate  surprisingly  threonine  transformation  transforming  tumorigenic 
Tagcloud (Difference) ?
16q  1q  affymetrix  classic  clustering  clusters  cytoskeleton  distinguished  epithelium  fresh  frozen  golm1  gpr137b  hierarchical  ilc  lcis  lobular  mastectomy  microarrays  microdissected  obligate  personalize  precursor  prophylactic  supervised  transcriptomic  triplets  u133a  unsupervised 
3t3  activate  bind  chimeric  cytoskeletal  dispensable  effector  effectors  interrelationship  jnk  jun  lamellipodia  lamellipodium  mediate  nh2  nih  p65  pak  ras  rho  rhoa  ruffling  srf  stimulate  surprisingly  threonine  transformation  transforming  tumorigenic 
Tagcloud (Intersection) ?