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PIK3R1 and HOXA1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PIK3R1
HOXA1
Description
phosphoinositide-3-kinase regulatory subunit 1
homeobox A1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Chromatin
Nucleus
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
GTPase Activator Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Kinase Regulator Activity
Kinase Activator Activity
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Phosphatidylinositol Kinase Activity
Enzyme-substrate Adaptor Activity
Phosphatidylinositol 3-kinase Activator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Intracellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Positive Regulation Of Leukocyte Migration
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Immune Response
Negative Regulation Of Cell Adhesion
Signal Transduction
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Protein Transport
Cytokine-mediated Signaling Pathway
B Cell Differentiation
T Cell Differentiation
Osteoclast Differentiation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Regulation Of Toll-like Receptor 4 Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Interleukin-18-mediated Signaling Pathway
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of D-glucose Import
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
T Follicular Helper Cell Differentiation
Myeloid Leukocyte Migration
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Sensory Perception Of Sound
Optokinetic Behavior
Anatomical Structure Morphogenesis
Abducens Nerve Formation
Outer Ear Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Neurocranium Morphogenesis
Inner Ear Development
Artery Morphogenesis
Regulation Of Behavior
Cognition
Neuromuscular Process
Artery Development
Semicircular Canal Formation
Cochlea Development
Cochlea Morphogenesis
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK in cancer
Signaling by LTK
Co-stimulation by ICOS
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
SF1126
Enzastaurin
Wortmannin
Diseases
Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
GWAS
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Appendicular lean mass (
33097823
)
Basal cell carcinoma (
33549134
)
Birth weight (
31043758
)
Body fat percentage and HDL-C (pairwise) (
33619380
)
Bone mineral density (hip) (
26911590
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
30604766
31152163
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Leg fat mass (lean adjusted) (
32719433
)
Leg fat mass and leg lean mass (pleiotropy) (
32719433
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
32203549
29083408
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Chronic venous disease (
28374850
)
Macular thickness (
30535121
)
Multiple sclerosis (
31604244
)
Small cell lung carcinoma (
28604730
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
180 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CIP2A
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FBXO21
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NLRP6
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTEN
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNK2
TNS4
TOM1L1
TRAT1
TRIM25
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
344 interacting genes:
ACOT7
ADAM12
ADAMTSL2
ADAMTSL4
AGAP3
AGRN
AGXT
ALG13
ALPP
AMMECR1
AMOT
ANKS1A
ARID5A
ARMC7
ATG9B
ATP23
ATXN2L
BAG4
BAHD1
BATF2
BEND5
BLCAP
BLZF1
BSCL2
BSDC1
BUD31
C11orf16
CATSPER1
CCDC120
CCDC33
CCN3
CCN4
CCN5
CCNK
CD163
CD164
CDPF1
CERCAM
CFAP68
CFP
CHIC2
CHRD
CHRDL2
CIRSR
CNFN
CNNM3
COL8A1
CREB5
CRELD1
CRELD2
CUTA
CXCL16
CYP21A2
CYSRT1
DBF4B
DCTN1
DGKQ
DKK3
DOCK2
DOCK3
DOK3
DRC4
DTX2
DUSP10
DUSP22
EEF1A1
EFEMP1
EFEMP2
EGFL7
ENKD1
EPDR1
ESM1
ESR2
EVA1B
FAAP100
FAM219B
FAM221A
FBLN1
FBLN2
FBLN5
FBN1
FHL3
FHL5
FN1
FOXH1
FOXN1
FRS3
FST
FUCA2
GATA1
GCM2
GDF15
GNE
GP9
GPRASP3
GPS2
GRN
GSTP1
GUCD1
HEXB
HEXIM2
HEY2
HOXB9
HR
HSD3B7
ID3
IGFL1
IGFN1
INCA1
INO80B
IRX6
ITGB4
JAG2
KCTD9
KDM1A
KPRP
KRT31
KRT33B
KRT34
KRT35
KRT37
KRT38
KRT40
KRT81
KRT82
KRT83
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP15-1
KRTAP19-6
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP23-1
KRTAP26-1
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LAMA5
LAMB2
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LGALS13
LGALS4
LIMS2
LMX1B
LNX1
LONRF1
LPXN
LTBP1
LTBP3
LTBP4
LUC7L2
MACO1
MAPKBP1
MDFI
MEGF6
MEGF8
MFAP2
MGAT5B
MKRN3
MLLT11
MYO15B
MYPOP
N4BP2L2
NBPF19
NCK2
NECTIN2
NEDD9
NEK6
NELL1
NELL2
NFKBID
NOTCH1
NOTCH2NLA
NOTCH3
NR1D2
NTN4
NUCB1
NXF1
ODF1
OIT3
OPLAH
OTX1
P2RY6
PAX6
PBX2
PCSK5
PCYOX1
PCYT2
PHETA1
PIK3R1
PIN1
PITX1
PITX2
PKM
PKNOX1
PLA2G10
PLEKHN1
PLLP
PLSCR1
PLSCR2
PLSCR3
PLSCR4
PRICKLE4
PRMT6
PROP1
PSMB1
PTH1R
PVR
PYCR3
QARS1
R3HDM1
RALGDS
RANBP3
RBCK1
RBP3
RBPMS
RCHY1
RGS17
RGS19
RGS20
RNF208
RSPO2
RTN4R
SAXO4
SCT
SDCBP
SIVA1
SLC15A3
SLC23A1
SLIT1
SLIT2
SLPI
SMCP
SND1
SNRPB
SNRPC
SPATA12
SPATA18
SPRY1
SPRY2
SPRY3
SPRY4
SSC4D
SSUH2
STX11
SUV39H1
TBC1D10C
TBR1
TBX15
TCF19
TCF3
TEKT4
TEKT5
TGFB1
TGFB1I1
TGM7
THAP7
TLE5
TNS2
TRAF1
TRAF2
TRAF4
TRAPPC6A
TRIM42
TRIM55
TRIM63
TRIM8
TRIP6
TSPAN4
UBL5
UNKL
VASN
VWC2
VWC2L
VWCE
VWF
WDR83
WWOX
YIPF3
YPEL3
ZBTB16
ZFTRAF1
ZIM2
ZMAT1
ZNF417
ZNF587
ZNF688
ZNF774
ZNF837
ZNF843
ZNRF3
Entrez ID
5295
3198
HPRD ID
01381
00843
Ensembl ID
ENSG00000145675
ENSG00000105991
Uniprot IDs
A0A2X0SFG1
P27986
E7ERT8
P49639
PDB IDs
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
7CIO
7LM2
7LQ1
7MYN
7MYO
7PG5
7PG6
7RNS
7TZ7
8AM0
8DCP
8DCX
8DD4
8DD8
8GUB
8H36
8H37
8ILR
8ILS
8ILV
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8V8H
8V8I
8V8J
8V8U
8V8V
8W9A
8W9B
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Regulation Of Signal Transduction
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Protein Kinase Activity
Regulation Of Immune Response
Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphorylation
Immune Response-regulating Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Protein Phosphorylation
Receptor Complex
Positive Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune Response
Cell Migration
Cytokine-mediated Signaling Pathway
Protein Autophosphorylation
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Migration
Activation Of Immune Response
Intermediate Filament
Keratin Filament
Keratinization
Protein Binding
Epidermis Development
Extracellular Matrix
Hair Cycle
Extracellular Matrix Structural Constituent
Structural Constituent Of Skin Epidermis
Tissue Development
Integrin Binding
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Calcium Ion Binding
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Intermediate Filament Organization
Basement Membrane
Microfibril
Identical Protein Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Developmental Process
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Animal Organ Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Phospholipid Scramblase Activity
Extracellular Region
Morphogenesis Of An Epithelium
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Plasma Membrane Phospholipid Scrambling
Anatomical Structure Morphogenesis
Elastic Fiber
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Structural Molecule Activity
Tissue Morphogenesis
Heparin Binding
Roundabout Binding
Embryonic Morphogenesis
Extracellular Space
Negative Regulation Of Biomineral Tissue Development
Embryonic Hindlimb Morphogenesis
Post-embryonic Eye Morphogenesis
Extracellular Matrix Assembly
Cell Fate Commitment
TRAF2-GSTP1 Complex
Vasculogenesis
Lead Ion Binding
Susceptibility To T Cell Mediated Cytotoxicity
Lung Growth
Regionalization
Skeletal System Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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