EIF3H and CCDC85B

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF3H	CCDC85B
Gene Name		eukaryotic translation initiation factor 3, subunit H	coiled-coil domain containing 85B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytoplasm Centrosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Transcription, DNA-templated Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Colorectal cancer ( 18372905 21761138) Corneal curvature ( 22969067)
Protein-Protein Interactions		8 interactors: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3	133 interactors: AGGF1 AKAP17A AKIRIN2 ALS2CR11 APEX2 AQP1 BEX2 C10orf10 C19orf25 C1orf111 C20orf195 C21orf91 C7orf50 C8orf48 CARD9 CCDC112 CCDC116 CCDC120 CCDC185 CCDC33 CCDC67 CCNK CDK18 CDKN1A CEP70 CFAP53 CHCHD3 COPS4 CWC25 DOK5 DTNB DUSP13 EIF3H ENKD1 EPS8 EXOC7 EXOC8 EZH2 FAM107A FAM124B FAM13C FAM208B FAM214B FAM27E3 FAM50B FAM74A4 FASTKD5 FBF1 FCHSD2 FXR2 GCC1 GFI1B GPANK1 HMG20B HNRNPC IKZF5 KANSL1 KIAA0408 KRT17 KRT18 KRT20 KRT6A LDOC1 LMO3 LNX1 LZTS2 MBIP MCM10 MCRS1 MEAF6 MOAP1 MOB1A MOB4 NDUFA5 NEK6 NGFRAP1 NIF3L1 NRIP1 NUP54 PBXIP1 PIDD1 PKN1 PLEKHF2 PLOD3 POLR2L PRC1 PRPF3 PSMA1 PSMC1 PSMC6 PSMF1 RALYL RBM41 RBM7 RIBC2 RNF8 SCNM1 SETD5 SF3A3 SIX1 SLU7 SMARCD1 SYT17 SYTL4 TCEANC TCHP TEAD4 THAP7 TNNI1 TNNT1 TSPYL4 TTC14 TTC25 TUBGCP4 USP2 UTP14A UTP6 VPS72 ZBTB16 ZBTB5 ZC2HC1C ZFC3H1 ZFP36 ZNF165 ZNF205 ZNF250 ZNF337 ZNF417 ZNF426 ZNF564 ZNF638 ZNF764 ZNF821
Entrez ID		8667	11007
HPRD ID		04885	16101
Ensembl ID			ENSG00000175602
Uniprot IDs		B3KS98 O15372 Q6IB98	Q15834
PDB IDs
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Positive Regulation Of Cytoskeleton Organization Regulation Of Translation Actin Filament Organization Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Posttranscriptional Regulation Of Gene Expression Regulation Of Cytoskeleton Organization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Actin Filament-based Process Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Cell Migration Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Motility Regulation Of Organelle Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Component Biogenesis Signal Complex Assembly Ribonucleoprotein Complex Biogenesis Mitochondrial Calcium Ion Homeostasis Locomotion Positive Regulation Of Signal Transduction Rac Protein Signal Transduction Regulation Of Synapse Maturation Regulation Of Arp2/3 Complex-mediated Actin Nucleation TOR Signaling Regulation Of Actin Nucleation	Gene Expression RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle RNA Biosynthetic Process Transcription, DNA-templated Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Regulation Of Gene Expression Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Mitotic G1 DNA Damage Checkpoint Organelle Organization Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Cellular Metabolic Process Positive Regulation Of Cell Cycle Arrest Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Process Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Programmed Cell Death DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition RNA Processing Mitotic DNA Integrity Checkpoint Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Death
Tagcloud ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat
Tagcloud (Difference) ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat
Tagcloud (Intersection) ?