CCDC85B and SIX1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCDC85B	SIX1
Description		coiled-coil domain containing 85B	SIX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoskeleton Adherens Junction Anchoring Junction	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm
	Molecular Function	Protein Binding Delta-catenin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Assembly At Neuromuscular Junction Gene Expression Regulation Of Gene Expression Neural Crest Cell Differentiation Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Neurogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Endothelin Receptor Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Myoblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Formation of the ureteric bud
Drugs
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 22419738 22570617 29891935) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Optic disc size ( 31809533) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946 25241763)
Interacting Genes		138 interacting genes: AGGF1 AKAP17A AKIRIN2 APEX2 AQP1 ATOSB BEX2 BEX3 BIRC5 C19orf25 C21orf91 C8orf48 CARD9 CATSPERT CCDC112 CCDC116 CCDC120 CCDC185 CCDC33 CCNK CDK18 CDKN1A CENPP CEP70 CFAP53 CHCHD3 CHLSN COPS4 CWC25 DEPP1 DEUP1 DOK5 DTNB DUSP13B EIF3H ENKD1 EPS8 EXOC7 EXOC8 EZH2 FAM107A FAM124B FAM13C FAM27E3 FAM50B FAM74A4 FASTKD5 FBF1 FCHSD2 FNDC11 FXR2 GCC1 GFI1B GPANK1 HMG20B HNRNPC IKZF5 INO80B KANSL1 KIAA0408 KRT17 KRT18 KRT20 KRT6A LDOC1 LMO3 LNX1 LZTS2 MBIP MCM10 MCRS1 MEAF6 MOAP1 MOB1A MOB4 NDUFA5 NEK6 NIF3L1 NRIP1 NUP54 ODAD4 PBXIP1 PIDD1 PKN1 PLEKHF2 PLOD3 POLR2L PRC1 PRPF3 PSMA1 PSMC1 PSMC6 PSMF1 RALYL RBM41 RBM7 RGS8 RIBC2 RNF8 SCNM1 SETD5 SF3A3 SIX1 SLU7 SMARCD1 SPATA46 SYT17 SYTL4 TASOR2 TCEANC TCHP TEAD4 THAP7 TNNI1 TNNT1 TSPYL4 TTC14 TUBGCP4 USP2 UTP14A UTP6 VPS72 ZBTB16 ZBTB5 ZC2HC1C ZFC3H1 ZFP36 ZNF165 ZNF205 ZNF250 ZNF337 ZNF417 ZNF426 ZNF564 ZNF587 ZNF638 ZNF764 ZNF821	14 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI PLEKHG4 POU6F2 REL TLE1 TLE3 TLE5 VTN
Entrez ID		11007	6495
HPRD ID		16101	03125
Ensembl ID		ENSG00000175602	ENSG00000126778
Uniprot IDs		Q15834	Q15475
PDB IDs			4EGC
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nuclear Speck Zinc Ion Binding Spindle Pole Spindle Midzone Assembly Keratin Filament Chromatin Organization Regulation Of RNA Metabolic Process	Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Phosphoprotein Phosphatase Activity Positive Regulation Of DNA Repair Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Mesodermal Cell Fate Specification Developmental Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Signaling Pathway Beta-catenin-TCF Complex Positive Regulation Of DNA Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Negative Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Transcription Corepressor Activity Anatomical Structure Morphogenesis DNA Repair Regulation Of Programmed Cell Death
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