EIF3H and SORBS3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF3H	SORBS3
Gene Name		eukaryotic translation initiation factor 3, subunit H	sorbin and SH3 domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Colorectal cancer ( 18372905 21761138) Corneal curvature ( 22969067)	HIV-1 control ( 20205591)
Protein-Protein Interactions		8 interactors: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3	46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		8667	10174
HPRD ID		04885	11535
Ensembl ID			ENSG00000120896
Uniprot IDs		B3KS98 O15372 Q6IB98	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Positive Regulation Of Cytoskeleton Organization Regulation Of Translation Actin Filament Organization Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Posttranscriptional Regulation Of Gene Expression Regulation Of Cytoskeleton Organization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Actin Filament-based Process Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Cell Migration Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Motility Regulation Of Organelle Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Component Biogenesis Signal Complex Assembly Ribonucleoprotein Complex Biogenesis Mitochondrial Calcium Ion Homeostasis Locomotion Positive Regulation Of Signal Transduction Rac Protein Signal Transduction Regulation Of Synapse Maturation Regulation Of Arp2/3 Complex-mediated Actin Nucleation TOR Signaling Regulation Of Actin Nucleation	Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat
Tagcloud (Difference) ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat
Tagcloud (Intersection) ?