EIF3H and EIF3G

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		EIF3H	EIF3G
Description		eukaryotic translation initiation factor 3 subunit H	eukaryotic translation initiation factor 3 subunit G
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal-dependent Deubiquitinase Activity	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Viral Translational Termination-reinitiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 21761138 30529582 29471430 18372905 26965516 26151821 25990418 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196 34021172)
Interacting Genes		14 interacting genes: ABI1 ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SNAI1 SORBS2 SORBS3 SPTBN1 UBC YAP1	29 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA MEOX2 METTL3 MIF4GD MPHOSPH6 OGT PALS2 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14
Entrez ID		8667	8666
HPRD ID		04885	04886
Ensembl ID		ENSG00000147677	ENSG00000130811
Uniprot IDs		O15372 Q6IB98	O75821
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	2CQ0 2MJC 5K0Y 6YBS 6ZMW 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8XXM 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Actin-based Cell Projection SCAR Complex Signaling Adaptor Activity Cytoskeletal Anchor Activity Postsynaptic Density Neuron Migration Lamellipodium Anchoring Junction Cytoplasm Regulation Of Cellular Component Organization Canonical Wnt Signaling Pathway Cell Migration Regulation Of Actin Filament Organization Structural Constituent Of Cytoskeleton Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Filopodium Tip Cytoskeleton Organization Cell Motility Regulation Of Actin Cytoskeleton Organization Regulation Of Postsynapse Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Organelle Organization Cytoplasmic Translational Initiation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Dendritic Spine Morphogenesis Lamellipodium Organization Cell Surface Receptor Signaling Pathway Synapse Translation Initiation Factor Activity Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Enterocyte Differentiation Regulation Of Cytoskeleton Organization Cytoskeleton Cytosol Regulation Of Cell Projection Assembly Negative Regulation Of Fat Cell Differentiation Mesoderm Development Actin Polymerization Or Depolymerization Actin Filament Organization Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Central Nervous System Formation Cell Projection Morphogenesis	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Translation Initiation Factor Activity Protein-containing Complex Assembly Protein-containing Complex Organization Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Cellular Component Assembly Regulation Of Translational Initiation Protein-RNA Complex Assembly Regulation Of Translation Viral Translational Termination-reinitiation Translation Post-transcriptional Regulation Of Gene Expression Cytoplasm IRES-dependent Viral Translational Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process RNA Binding Cytosol Telomere Assembly Protein Tetramerization Protein Metabolic Process Nucleus Phosphoprotein Binding Cap-dependent Translational Initiation Shelterin Complex Negative Regulation Of Protein Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process Nuclear Telomere Cap Complex Positive Regulation Of Translation Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Telomere Capping Protein-containing Complex Establishment Of Protein Localization To Organelle Regulation Of ATP Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Body Regulation Of Purine Nucleotide Metabolic Process Regulation Of Protein Catabolic Process
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