EIF3H and SNAI1

Number of citations of the paper that reports this interaction (PubMedID 32867821)
67

Data Source:
BioGRID (enzymatic study)

		EIF3H	SNAI1
Description		eukaryotic translation initiation factor 3 subunit H	snail family transcriptional repressor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal-dependent Deubiquitinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 21761138 30529582 29471430 18372905 26965516 26151821 25990418 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196 34021172)	Psoriasis ( 20953189)
Interacting Genes		14 interacting genes: ABI1 ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SNAI1 SORBS2 SORBS3 SPTBN1 UBC YAP1	49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3
Entrez ID		8667	6615
HPRD ID		04885	05025
Ensembl ID		ENSG00000147677	ENSG00000124216
Uniprot IDs		O15372 Q6IB98	O95863
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7
Enriched GO Terms of Interacting Partners?		Actin-based Cell Projection SCAR Complex Signaling Adaptor Activity Cytoskeletal Anchor Activity Postsynaptic Density Neuron Migration Lamellipodium Anchoring Junction Cytoplasm Regulation Of Cellular Component Organization Canonical Wnt Signaling Pathway Cell Migration Regulation Of Actin Filament Organization Structural Constituent Of Cytoskeleton Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Filopodium Tip Cytoskeleton Organization Cell Motility Regulation Of Actin Cytoskeleton Organization Regulation Of Postsynapse Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Organelle Organization Cytoplasmic Translational Initiation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Dendritic Spine Morphogenesis Lamellipodium Organization Cell Surface Receptor Signaling Pathway Synapse Translation Initiation Factor Activity Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Enterocyte Differentiation Regulation Of Cytoskeleton Organization Cytoskeleton Cytosol Regulation Of Cell Projection Assembly Negative Regulation Of Fat Cell Differentiation Mesoderm Development Actin Polymerization Or Depolymerization Actin Filament Organization Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Central Nervous System Formation Cell Projection Morphogenesis	Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication
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