EIF3H and DISC1

Number of citations of the paper that reports this interaction (PMID 12812986)
80

Data Source:
HPRD (in vivo, two hybrid)

		EIF3H	DISC1
Gene Name		eukaryotic translation initiation factor 3, subunit H	disrupted in schizophrenia 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Colorectal cancer ( 18372905 21761138) Corneal curvature ( 22969067)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		8 interactors: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		8667	27185
HPRD ID		04885	05553
Ensembl ID			ENSG00000162946
Uniprot IDs		B3KS98 O15372 Q6IB98	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Positive Regulation Of Cytoskeleton Organization Regulation Of Translation Actin Filament Organization Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Posttranscriptional Regulation Of Gene Expression Regulation Of Cytoskeleton Organization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Actin Filament-based Process Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Cell Migration Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Motility Regulation Of Organelle Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Component Biogenesis Signal Complex Assembly Ribonucleoprotein Complex Biogenesis Mitochondrial Calcium Ion Homeostasis Locomotion Positive Regulation Of Signal Transduction Rac Protein Signal Transduction Regulation Of Synapse Maturation Regulation Of Arp2/3 Complex-mediated Actin Nucleation TOR Signaling Regulation Of Actin Nucleation	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?