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CCDC85B and POLR2L
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CCDC85B
POLR2L
Gene Name
coiled-coil domain containing 85B
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Nucleus
Nucleoplasm
DNA-directed RNA Polymerase II, Core Complex
DNA-directed RNA Polymerase III Complex
DNA-directed RNA Polymerase I Complex
Cytosol
Molecular Function
Protein Binding
RNA Polymerase I Activity
RNA Polymerase II Activity
RNA Polymerase III Activity
DNA Binding
DNA-directed RNA Polymerase Activity
Zinc Ion Binding
Biological Process
Transcription, DNA-templated
Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
MRNA Splicing, Via Spliceosome
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Regulation Of Transcription From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Transcription From RNA Polymerase III Promoter
Transcription Elongation From RNA Polymerase III Promoter
Termination Of RNA Polymerase III Transcription
RNA Splicing
Gene Expression
Viral Process
Positive Regulation Of Type I Interferon Production
PiRNA Metabolic Process
Somatic Stem Cell Maintenance
Regulation Of Gene Expression, Epigenetic
Innate Immune Response
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Pathways
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Regulatory RNA pathways
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
Formation of transcription-coupled NER (TC-NER) repair complex
Dual incision reaction in TC-NER
Influenza Life Cycle
RNA Polymerase III Transcription Termination
HIV elongation arrest and recovery
NoRC negatively regulates rRNA expression
Influenza Viral RNA Transcription and Replication
RNA Polymerase III Chain Elongation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation From Type 1 Promoter
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
MicroRNA (miRNA) biogenesis
Influenza Infection
Pausing and recovery of Tat-mediated HIV elongation
Late Phase of HIV Life Cycle
RNA Polymerase III Transcription Initiation From Type 2 Promoter
Formation of RNA Pol II elongation complex
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Abortive And Retractive Initiation
Transcription of the HIV genome
Nucleotide Excision Repair
PIWI-interacting RNA (piRNA) biogenesis
mRNA Splicing
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase II Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
Transcriptional regulation of pluripotent stem cells
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Innate Immune System
RNA Polymerase III Transcription Initiation
Transcriptional regulation by small RNAs
Processing of Capped Intron-Containing Pre-mRNA
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Cytosolic sensors of pathogen-associated DNA
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Pausing and recovery of HIV elongation
Formation of the HIV-1 Early Elongation Complex
Viral Messenger RNA Synthesis
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions
133 interactors:
AGGF1
AKAP17A
AKIRIN2
ALS2CR11
APEX2
AQP1
BEX2
C10orf10
C19orf25
C1orf111
C20orf195
C21orf91
C7orf50
C8orf48
CARD9
CCDC112
CCDC116
CCDC120
CCDC185
CCDC33
CCDC67
CCNK
CDK18
CDKN1A
CEP70
CFAP53
CHCHD3
COPS4
CWC25
DOK5
DTNB
DUSP13
EIF3H
ENKD1
EPS8
EXOC7
EXOC8
EZH2
FAM107A
FAM124B
FAM13C
FAM208B
FAM214B
FAM27E3
FAM50B
FAM74A4
FASTKD5
FBF1
FCHSD2
FXR2
GCC1
GFI1B
GPANK1
HMG20B
HNRNPC
IKZF5
KANSL1
KIAA0408
KRT17
KRT18
KRT20
KRT6A
LDOC1
LMO3
LNX1
LZTS2
MBIP
MCM10
MCRS1
MEAF6
MOAP1
MOB1A
MOB4
NDUFA5
NEK6
NGFRAP1
NIF3L1
NRIP1
NUP54
PBXIP1
PIDD1
PKN1
PLEKHF2
PLOD3
POLR2L
PRC1
PRPF3
PSMA1
PSMC1
PSMC6
PSMF1
RALYL
RBM41
RBM7
RIBC2
RNF8
SCNM1
SETD5
SF3A3
SIX1
SLU7
SMARCD1
SYT17
SYTL4
TCEANC
TCHP
TEAD4
THAP7
TNNI1
TNNT1
TSPYL4
TTC14
TTC25
TUBGCP4
USP2
UTP14A
UTP6
VPS72
ZBTB16
ZBTB5
ZC2HC1C
ZFC3H1
ZFP36
ZNF165
ZNF205
ZNF250
ZNF337
ZNF417
ZNF426
ZNF564
ZNF638
ZNF764
ZNF821
23 interactors:
BANP
CCDC85B
CHEK2
COIL
EXOSC5
L3MBTL3
NFKBIB
NOV
PHC2
POLR2A
POLR2B
POLR2C
POLR2D
POLR2E
POLR2G
POLR2H
REL
RPAP1
SNX7
SPAG5
THAP1
TP53BP2
ZBTB14
Entrez ID
11007
5441
HPRD ID
16101
01155
Ensembl ID
ENSG00000175602
ENSG00000177700
Uniprot IDs
Q15834
P62875
PDB IDs
Enriched GO Terms of Interacting Partners
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Gene Expression
RNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cell Cycle
RNA Biosynthetic Process
Transcription, DNA-templated
Mitotic Cell Cycle Process
Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Regulation Of Gene Expression
Signal Transduction Involved In Cell Cycle Checkpoint
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Nitrogen Compound Metabolic Process
Mitotic G1 DNA Damage Checkpoint
Organelle Organization
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Cellular Metabolic Process
Positive Regulation Of Cell Cycle Arrest
Cell Cycle Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Transcription, DNA-templated
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Apoptotic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Signal Transduction In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Regulation Of RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Programmed Cell Death
DNA Damage Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
RNA Processing
Mitotic DNA Integrity Checkpoint
Cellular Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Death
7-methylguanosine MRNA Capping
PiRNA Metabolic Process
7-methylguanosine RNA Capping
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Viral Transcription
Transcription Elongation From RNA Polymerase II Promoter
Somatic Stem Cell Maintenance
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
DNA-templated Transcription, Elongation
Nucleotide-excision Repair
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Stem Cell Maintenance
Regulation Of Viral Process
Gene Expression
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Stem Cell Development
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
NcRNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Stem Cell Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
MRNA Metabolic Process
RNA Splicing
Cellular Nitrogen Compound Metabolic Process
DNA Repair
Transcription From RNA Polymerase II Promoter
MRNA Processing
Nitrogen Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Cell Differentiation
DNA Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Viral Process
Cellular Response To DNA Damage Stimulus
Regulation Of RNA Metabolic Process
RNA Processing
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Cell Development
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