IRS2 and SIRT1

  • Number of citations of the paper that reports this interaction (PMID 17901049)
  • 32
  • Data Source:
  • BioGRID (enzymatic study)

IRS2

SIRT1

Gene Name insulin receptor substrate 2 sirtuin 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ 47 interactors: AKT1 ARNTL BCL11A BHLHE41 CDK6 CSNK2B CTTN EP300 ESRRA FOS FOXO1 FOXO3 GAPDH HES1 HEY2 HIC1 HIST1H1B HIST1H3A HNF4A IRS2 MAPK8 MAPT MYCN NBN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARGC1A PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 SREBF1 STK11 STK4 TP53 UBE2I VDR
Entrez ID 8660 23411
HPRD ID 02878 08381
Ensembl ID ENSG00000185950 ENSG00000096717
Uniprot IDs Q9P084 Q9Y4H2 A8K128 B0QZ35 E9PC49 Q96EB6
PDB IDs 3FQW 3FQX 4I5I
Enriched GO Terms of Interacting Partners?
Tagcloud ?
aacr  adaptive  adaptor  compensatory  conversely  cotargeting  dampen  dasatinib  ddr2  driven  emerged  gab1  harboring  igf1r  implicating  library  met  option  overlaying  panel  phosphoproteomics  py  rationale  res  rescued  rtk  scc  synergistic  weakly 
1alpha  adipose  adrenergic  alternate  atgl  biogenesis  catalyzed  coactivator  coregulator  deacetylase  deacetylation  fatty  identifies  links  lipase  lipolysis  mediates  metabolism  nad  oxidative  partner  peroxisome  pgc  ppar  presumed  proliferator  promote  sirtuin  triglyceride 
Tagcloud (Difference) ?
aacr  adaptive  adaptor  compensatory  conversely  cotargeting  dampen  dasatinib  ddr2  driven  emerged  gab1  harboring  igf1r  implicating  library  met  option  overlaying  panel  phosphoproteomics  py  rationale  res  rescued  rtk  scc  synergistic  weakly 
1alpha  adipose  adrenergic  alternate  atgl  biogenesis  catalyzed  coactivator  coregulator  deacetylase  deacetylation  fatty  identifies  links  lipase  lipolysis  mediates  metabolism  nad  oxidative  partner  peroxisome  pgc  ppar  presumed  proliferator  promote  sirtuin  triglyceride 
Tagcloud (Intersection) ?