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SIRT1 and HEY2
Number of citations of the paper that reports this interaction (PubMedID
12535671
)
0
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro, in vivo)
SIRT1
HEY2
Description
sirtuin 1
hes related family bHLH transcription factor with YRPW motif 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
Protein-containing Complex
RDNA Heterochromatin
ESC/E(Z) Complex
ENoSc Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Enzyme Inhibitor Activity
Protein Binding
Enzyme Activator Activity
Transferase Activity
Nuclear Receptor Binding
Histone Deacetylase Activity, NAD-dependent
Deacetylase Activity
Enzyme Binding
Protein Domain Specific Binding
Histone H3K14 Deacetylase Activity, NAD-dependent
Protein Lysine Deacetylase Activity
NAD-dependent Protein Lysine Deacetylase Activity
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Histone H3K9 Deacetylase Activity, NAD-dependent
Histone H4K16 Deacetylase Activity, NAD-dependent
Mitogen-activated Protein Kinase Binding
NAD+ Binding
NAD-dependent Protein-lysine Depropionylase Activity
DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism
Histone H3K Deacetylase Activity
NAD-dependent Protein Lysine Delactylase Activity
NAD-dependent Protein Decrotonylase Activity
Histone Decrotonylase Activity, NAD-dependent
Keratin Filament Binding
NAD+-protein Mono-ADP-ribosyltransferase Activity
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Formation
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Intracellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Gluconeogenesis
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Protein Deacetylation
Triglyceride Mobilization
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Negative Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Peptidyl-lysine Acetylation
Triglyceride Biosynthetic Process
Cell Differentiation
Macrophage Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Formation
Subtelomeric Heterochromatin Formation
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Hippo Signaling
Negative Regulation Of Hippo Signaling
Intracellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Cellular Response To Glucose Starvation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By Glucose
Positive Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Lipid Biosynthetic Process
Rhythmic Process
Regulation Of Developmental Process
White Fat Cell Differentiation
Positive Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Multicellular Organismal Process
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Maintenance Of Nucleus Location
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of Small Molecule Metabolic Process
Cellular Response To Hydrogen Peroxide
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Signal Transduction By P53 Class Mediator
Tricarboxylic Acid Metabolic Process
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Energy Homeostasis
Protein Depropionylation
DNA Repair-dependent Chromatin Remodeling
Regulation Of Cellular Response To Heat
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Positive Regulation Of Adipose Tissue Development
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Vasculogenesis
Muscular Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Development
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Tricuspid Valve Morphogenesis
Tricuspid Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation
Cardiac Ventricle Morphogenesis
Cardiac Left Ventricle Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Cardiac Muscle Hypertrophy
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Notch Signaling Pathway
Pattern Specification Process
Heart Development
Anatomical Structure Morphogenesis
Anterior/posterior Axis Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Heart Rate
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Mesenchymal Cell Development
Cardiac Muscle Hypertrophy In Response To Stress
Ascending Aorta Morphogenesis
Dorsal Aorta Morphogenesis
Umbilical Cord Morphogenesis
Cell Fate Commitment
Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurogenesis
Smooth Muscle Cell Differentiation
Negative Regulation Of Smooth Muscle Cell Differentiation
Ventricular Cardiac Muscle Cell Development
Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Epithelial To Mesenchymal Transition
Heart Trabecula Formation
Cardiac Septum Morphogenesis
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Negative Regulation Of Transcription Initiation By RNA Polymerase II
Labyrinthine Layer Blood Vessel Development
Blood Vessel Endothelial Cell Differentiation
Artery Development
Arterial Endothelial Cell Differentiation
Cardiac Vascular Smooth Muscle Cell Development
Coronary Vasculature Morphogenesis
Pulmonary Artery Morphogenesis
Protein-DNA Complex Assembly
Negative Regulation Of Biomineral Tissue Development
Circulatory System Development
Cochlea Development
Vascular Associated Smooth Muscle Cell Development
Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Regulation Of Vasculogenesis
Pathways
Regulation of HSF1-mediated heat shock response
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Heme signaling
Negative Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of MITF-M dependent genes involved in metabolism
Transcriptional and post-translational regulation of MITF-M expression and activity
Expression of BMAL (ARNTL), CLOCK, and NPAS2
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Cardiogenesis
Drugs
Resveratrol
Selisistat
Cambinol
Diseases
GWAS
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Brugada syndrome (
23872634
35210625
32619740
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
27135401
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometrial endometrioid carcinoma (
27135401
)
Midgestational circulating levels of PCBs (fetal genetic effect) (
28235828
)
Migraine (
27322543
)
Night sleep phenotypes (
27126917
)
Serum metabolite concentrations in chronic kidney disease (
33838163
)
Subcortical volume (MOSTest) (
32665545
)
TPE interval (resting) (
32386560
)
Waist-hip index (
34021172
)
Interacting Genes
69 interacting genes:
AFP
AKT1
AR
BAZ1B
BCL11A
BHLHE41
BMAL1
BRIP1
CCAR2
CDK2
CDK6
CENATAC
CHFR
CLOCK
CTTN
CUL4B
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
FZR1
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MCL1
MPHOSPH8
MYCN
NBN
NDN
NEDD8
NMNAT1
NR1H2
NR1H3
NR1H4
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RPS19BP1
RRP8
SATB1
SETD7
SMAD7
SNW1
SOX2-OT
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
VDR
27 interacting genes:
ARNT
ATXN1
CYSRT1
ENO1
FHL5
HAND1
HAND2
HDAC1
HES1
HOXA1
HSF2BP
KRTAP1-1
KRTAP11-1
KRTAP3-1
KRTAP4-4
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP8-1
NCOR1
PDLIM7
PLSCR1
RBPMS
SIN3A
SIRT1
TRAF1
TRAF4
Entrez ID
23411
23493
HPRD ID
08381
05243
Ensembl ID
ENSG00000096717
ENSG00000135547
Uniprot IDs
A8K128
B0QZ35
E9PC49
Q96EB6
Q5TF93
Q9UBP5
PDB IDs
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
8ANB
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Chromatin
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Sequence-specific DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Biosynthetic Process
DNA Damage Response
DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Signal Transduction By P53 Class Mediator
Nuclear Receptor Activity
Negative Regulation Of Developmental Process
Intracellular Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Macromolecule Metabolic Process
Regulation Of Cell Differentiation
Chromatin DNA Binding
Rhythmic Process
Regulation Of Developmental Process
Regulation Of Cell Cycle
Intermediate Filament
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Corepressor Activity
Regulation Of Androgen Receptor Signaling Pathway
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
HLH Domain Binding
Cardiac Right Ventricle Formation
Keratin Filament
Chromatin
Regulation Of Transcription By RNA Polymerase II
Cytosol
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Identical Protein Binding
Histone Deacetylase Complex
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Metabolic Process
Cardiac Neural Crest Cell Development Involved In Heart Development
Regulation Of Secondary Heart Field Cardioblast Proliferation
Determination Of Heart Left/right Asymmetry
Transcription Corepressor Binding
Cardiac Ventricle Formation
Negative Regulation Of Transcription By RNA Polymerase II
Cartilage Morphogenesis
E-box Binding
Regulation Of Cardioblast Proliferation
Thioesterase Binding
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Gliogenesis
Transcription Repressor Complex
Artery Morphogenesis
Cardiac Chamber Formation
Protein Dimerization Activity
Regulation Of Cellular Response To Growth Factor Stimulus
DNA Binding
Protein Deacetylation
Protein Lysine Deacetylase Activity
Odontogenesis Of Dentin-containing Tooth
Embryonic Heart Tube Morphogenesis
Regulation Of Phosphorus Metabolic Process
Regulation Of ATP Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Purine Nucleotide Metabolic Process
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Tagcloud (Intersection)
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