SIRT1 and SMAD7

Number of citations of the paper that reports this interaction (PMID 17098745)
42

Data Source:
BioGRID (pull down)

		SIRT1	SMAD7
Gene Name		sirtuin 1	SMAD family member 7
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nuclear Euchromatin Nuclear Heterochromatin Nucleolus Cytoplasm Mitochondrion PML Body RDNA Heterochromatin ESC/E(Z) Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Catenin Complex Protein Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding P53 Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Keratin Filament Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Beta-catenin Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Activin Binding I-SMAD Binding
	Biological Process	Single Strand Break Repair Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Adaptive Immune Response DNA Replication DNA Repair Chromatin Organization Chromatin Silencing Establishment Of Chromatin Silencing Maintenance Of Chromatin Silencing Methylation-dependent Chromatin Silencing Transcription, DNA-templated RRNA Processing Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To Starvation Gene Expression Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Viral Process Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Protein Destabilization Positive Regulation Of Chromatin Silencing Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Response To Endoplasmic Reticulum Stress Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Neuron Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein Complex Localization Intracellular Signal Transduction Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Colorectal cancer ( 18372901 18372905 21761138 17934461 23266556) Dental caries ( 23064961) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		47 interactors: AKT1 ARNTL BCL11A BHLHE41 CDK6 CSNK2B CTTN EP300 ESRRA FOS FOXO1 FOXO3 GAPDH HES1 HEY2 HIC1 HIST1H1B HIST1H3A HNF4A IRS2 MAPK8 MAPT MYCN NBN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARGC1A PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 SREBF1 STK11 STK4 TP53 UBE2I VDR	54 interactors: ACVR1B AKT1 ASH1L AXIN1 BMPR1B CTNNB1 CXXC5 DVL1 EP300 ERBB2IP HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MKL2 MYOD1 NEDD4L PARD3 PARD3B PIAS1 PIAS4 RNF111 SASH3 SIRT1 SMAD2 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107
Entrez ID		23411	4092
HPRD ID		08381	04241
Ensembl ID		ENSG00000096717	ENSG00000101665
Uniprot IDs		A8K128 B0QZ35 E9PC49 Q96EB6	B3KYA8 O15105
PDB IDs		4I5I	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Cellular Response To Hormone Stimulus Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development Intracellular Receptor Signaling Pathway System Development Response To Hormone Response To Organic Substance Regulation Of Signaling Developmental Process RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Signaling Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression RNA Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Substance Tissue Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression
Tagcloud ?		1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride	adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate
Tagcloud (Difference) ?		1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride	adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate
Tagcloud (Intersection) ?