SIRT1 and HES1

Number of citations of the paper that reports this interaction (PubMedID 12535671)
0

Data Source:
HPRD (in vivo)

		SIRT1	HES1
Description		sirtuin 1	hes family bHLH transcription factor 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Mitochondrion Cytosol PML Body Protein-containing Complex RDNA Heterochromatin ESC/E(Z) Complex ENoSc Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Transferase Activity Nuclear Receptor Binding Histone Deacetylase Activity, NAD-dependent Deacetylase Activity Enzyme Binding Protein Domain Specific Binding Histone H3K14 Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent Histone H4K16 Deacetylase Activity, NAD-dependent Mitogen-activated Protein Kinase Binding NAD+ Binding NAD-dependent Protein-lysine Depropionylase Activity DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Histone H3K Deacetylase Activity NAD-dependent Protein Lysine Delactylase Activity NAD-dependent Protein Decrotonylase Activity Histone Decrotonylase Activity, NAD-dependent Keratin Filament Binding NAD+-protein Mono-ADP-ribosyltransferase Activity Promoter-specific Chromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding JUN Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding HLH Domain Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Protein-folding Chaperone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding N-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Single Strand Break Repair Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Intracellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Adaptive Immune Response Gluconeogenesis Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Deacetylation Triglyceride Mobilization Apoptotic Process DNA Damage Response Response To Oxidative Stress Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Starvation Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Positive Regulation Of Macroautophagy Protein Ubiquitination Peptidyl-lysine Acetylation Triglyceride Biosynthetic Process Cell Differentiation Macrophage Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Prostaglandin Biosynthetic Process Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Leptin-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Hippo Signaling Negative Regulation Of Hippo Signaling Intracellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Cellular Response To Glucose Starvation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Leptin Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By Glucose Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Lipid Biosynthetic Process Rhythmic Process Regulation Of Developmental Process White Fat Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Multicellular Organismal Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process UV-damage Excision Repair Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Signal Transduction By P53 Class Mediator Tricarboxylic Acid Metabolic Process Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Energy Homeostasis Protein Depropionylation DNA Repair-dependent Chromatin Remodeling Regulation Of Cellular Response To Heat Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Adipose Tissue Development Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Inhibition Of Neuroepithelial Cell Differentiation Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Pancreatic A Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Pattern Specification Process Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Cajal-Retzius Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Pituitary Gland Development Adenohypophysis Development Neuron Differentiation Lung Development BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Midbrain Development Pancreas Development Somatic Stem Cell Population Maintenance Hair Cell Differentiation Amacrine Cell Differentiation Aorta Morphogenesis Ascending Aorta Morphogenesis T Cell Proliferation Positive Regulation Of T Cell Proliferation Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein-containing Complex Assembly Response To Alkaloid Positive Regulation Of DNA Binding Cell Fate Commitment Negative Regulation Of Cell Differentiation Regulation Of Fat Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Maturation Regulation Of Timing Of Cell Differentiation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Inner Ear Receptor Cell Stereocilium Organization Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Establishment Of Epithelial Cell Polarity Negative Regulation Of Calcium Ion Import Response To Thyroid Hormone Vascular Associated Smooth Muscle Cell Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Amacrine Cell Differentiation Response To Aroclor 1254 Negative Regulation Of Cell Fate Determination Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways		Regulation of HSF1-mediated heat shock response SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation Heme signaling Negative Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of MITF-M dependent genes involved in metabolism Transcriptional and post-translational regulation of MITF-M expression and activity Expression of BMAL (ARNTL), CLOCK, and NPAS2	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Resveratrol Selisistat Cambinol
Diseases
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Diverticular disease ( 30177863) Molybdenum levels ( 26025379) Pulse pressure ( 30224653)	Alcoholic chronic pancreatitis ( 28754779) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Thyroid stimulating hormone levels ( 30367059 32769997)
Interacting Genes		69 interacting genes: AFP AKT1 AR BAZ1B BCL11A BHLHE41 BMAL1 BRIP1 CCAR2 CDK2 CDK6 CENATAC CHFR CLOCK CTTN CUL4B E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 FZR1 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MCL1 MPHOSPH8 MYCN NBN NDN NEDD8 NMNAT1 NR1H2 NR1H3 NR1H4 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RPS19BP1 RRP8 SATB1 SETD7 SMAD7 SNW1 SOX2-OT STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I VDR	36 interacting genes: ALK APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NHLH2 NR4A1 NUDT3 PRKCA PTK2 RUNX2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB
Entrez ID		23411	3280
HPRD ID		08381	00770
Ensembl ID		ENSG00000096717	ENSG00000114315
Uniprot IDs		A8K128 B0QZ35 E9PC49 Q96EB6	Q14469
PDB IDs		4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR 8ANB	2MH3 7C4O
Enriched GO Terms of Interacting Partners?		Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process DNA Damage Response DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Signal Transduction By P53 Class Mediator Nuclear Receptor Activity Negative Regulation Of Developmental Process Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Differentiation Chromatin DNA Binding Rhythmic Process Regulation Of Developmental Process Regulation Of Cell Cycle	Fanconi Anaemia Nuclear Complex Regulation Of Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Protein Dimerization Activity Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Population Proliferation Interstrand Cross-link Repair Animal Organ Development Negative Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleoplasm Cell Differentiation Regulation Of Developmental Process Circadian Rhythm Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Transcription Regulator Complex Neuron Differentiation Rhythmic Process Animal Organ Morphogenesis Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Anatomical Structure Morphogenesis
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