SIRT1 and PSME3

Number of citations of the paper that reports this interaction (PMID 23612972)
3

Data Source:
BioGRID (enzymatic study)

		SIRT1	PSME3
Gene Name		sirtuin 1	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nuclear Euchromatin Nuclear Heterochromatin Nucleolus Cytoplasm Mitochondrion PML Body RDNA Heterochromatin ESC/E(Z) Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding P53 Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Keratin Filament Binding	P53 Binding Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Single Strand Break Repair Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Adaptive Immune Response DNA Replication DNA Repair Chromatin Organization Chromatin Silencing Establishment Of Chromatin Silencing Maintenance Of Chromatin Silencing Methylation-dependent Chromatin Silencing Transcription, DNA-templated RRNA Processing Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To Starvation Gene Expression Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Viral Process Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Protein Destabilization Positive Regulation Of Chromatin Silencing Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Response To Endoplasmic Reticulum Stress Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Neuron Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Positive Regulation Of Endopeptidase Activity Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AKT1 ARNTL BCL11A BHLHE41 CDK6 CSNK2B CTTN EP300 ESRRA FOS FOXO1 FOXO3 GAPDH HES1 HEY2 HIC1 HIST1H1B HIST1H3A HNF4A IRS2 MAPK8 MAPT MYCN NBN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARGC1A PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 SREBF1 STK11 STK4 TP53 UBE2I VDR	35 interactors: ADAP1 AICDA ATN1 ATP5B BBS2 CASP3 CASP6 CASP7 COIL CREBBP DIP2A DTNBP1 EAF1 FBXO7 FXR2 HSPA5 ITPKB KANSL1 MDM2 NCOA3 NUDT18 PFDN5 PRKAB2 PRR13 SERF2 SIRT1 SMURF1 SPG7 TBXA2R TNFAIP8L1 TP53 TXN2 WDR25 YWHAQ ZCCHC10
Entrez ID		23411	10197
HPRD ID		08381	05500
Ensembl ID		ENSG00000096717	ENSG00000131467
Uniprot IDs		A8K128 B0QZ35 E9PC49 Q96EB6	P61289 Q6MZZ1
PDB IDs		4I5I
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Cellular Response To Hormone Stimulus Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development Intracellular Receptor Signaling Pathway System Development Response To Hormone Response To Organic Substance Regulation Of Signaling Developmental Process RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Signaling Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process	Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Helicase Activity Cellular Response To Extracellular Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrion Organization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Peptidyl-lysine Acetylation Peptidyl-lysine Modification Positive Regulation Of Cell Aging Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction Apoptotic Process Protein Acetylation Glial Cell Apoptotic Process Programmed Cell Death Regulation Of Gene Expression Anatomical Structure Development Response To Hypoxia Developmental Process Cell Death Death Mitochondrial Transport Response To Organic Substance Regulation Of Cellular Process Neuron Apoptotic Process Response To Antibiotic Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis ER Overload Response Apoptotic Signaling Pathway Neuron Death Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Intracellular Transport Proteolysis Multicellular Organismal Development Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Execution Phase Of Apoptosis Cellular Response To Oxidative Stress
Tagcloud ?		1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride	11sgamma amplification balance basal bioinformatics biotinylated called cdna ends export feedback immunoprecipitation ligase loop luciferase maintains negatively p53 pa28gamma precipitation promoter promotes promoting race reggamma regulates rlm start utilizing
Tagcloud (Difference) ?		1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride	11sgamma amplification balance basal bioinformatics biotinylated called cdna ends export feedback immunoprecipitation ligase loop luciferase maintains negatively p53 pa28gamma precipitation promoter promotes promoting race reggamma regulates rlm start utilizing
Tagcloud (Intersection) ?