SOCS1 and ERBB2

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		SOCS1	ERBB2
Gene Name		suppressor of cytokine signaling 1	erb-b2 receptor tyrosine kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Membrane-bounded Vesicle	Nucleus Cytoplasm Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Fat Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Amino Acid Stimulus	Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Cell Growth Positive Regulation Of Rho GTPase Activity Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Fc-epsilon Receptor Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interferon Signaling Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Signaling by SCF-KIT Toll Like Receptor 2 (TLR2) Cascade Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Regulation of KIT signaling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Innate Immune System Growth hormone receptor signaling Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Axon guidance PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Trastuzumab Lapatinib ado-trastuzumab emtansine Pertuzumab Afatinib
Diseases
GWAS		Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease and psoriasis ( 22482804) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		40 interactors: ATM AXL COMMD1 CRK CSF1 CSF1R CXCR4 CYTIP EGFR ERBB2 FLT3 FYN GHR GRB2 IFNGR1 IGF1R IL2RB INSR IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 RELA TCEB1 TCEB2 TEC TEK TIRAP TRIM8 VAV1 VAV2	110 interactors: ABL1 ABL2 ACPP ANKS1A ANKS1B APBB1 APBB3 BCAR3 BLK BLNK BMX BTC CAV1 CBL CD82 CHN1 CISH CLNK CRK CRKL CTNNB1 DAB1 DLG4 DOK1 DOK4 DOK6 EGF EGFR ERBB2IP ERBB3 ERBB4 ERRFI1 ESR1 FER FGR GRAP2 GRB2 GRB7 HDAC6 HLA-A HSP90AA1 HSP90B1 IL6ST IRS1 IRS4 ITGA5 ITGB4 ITK JAK1 JAK2 JUP MAPK8IP1 MAPK8IP2 MATK MUC1 MUC4 NCK2 NF2 NRG1 PAK1 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK2 PTK2B PTPN11 PTPN18 RASA1 RIN1 RIN2 SERPINA3 SH2B2 SH2B3 SH2D1B SH2D2A SH2D3A SH2D5 SH3BGRL3 SH3BP2 SHC1 SHC2 SHC3 SLA SLA2 SOCS1 SOS1 SRC SRPK1 STAT1 STAT3 STUB1 SUPT6H SYK TEC TGFA TLN1 TNS2 TNS3 TOB1 TXK UBB USP2 VAV1 VAV2 VAV3
Entrez ID		8651	2064
HPRD ID		04669	01281
Ensembl ID		ENSG00000185338	ENSG00000141736
Uniprot IDs		O15524 Q4JHT5	P04626
PDB IDs			1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 4GFU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Protein Autophosphorylation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Response To Stress Phosphatidylinositol-mediated Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Activation Cellular Response To Stimulus Response To Peptide Hormone Cellular Response To Growth Factor Stimulus Signaling Response To Growth Factor Response To Peptide Cell Communication Positive Regulation Of Kinase Activity Response To Stimulus Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Communication Signaling Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stimulus Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Stimulus Regulation Of Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Catalytic Activity Response To Organic Substance Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Process Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Cell Motility Cell Migration Wound Healing Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus
Tagcloud ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?