SOCS1 and MIR924HG

Number of citations of the paper that reports this interaction (PubMedID 32831137)
37

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		SOCS1	MIR924HG
Description		suppressor of cytokine signaling 1	MIR924 host gene
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Kinase Inhibitor Activity Cytokine Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding
	Biological Process	Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Macrophage Differentiation Developmental Process Intracellular Signal Transduction Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways		Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergy ( 27182965) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 29273806) Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease ( 28067908) Crohn's disease and psoriasis ( 22482804) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 27399966 26502338)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Depression ( 29700475) Pursuit maintenance gain ( 29064472) Schizophrenia (MTAG) ( 32107650)
Interacting Genes		54 interacting genes: AXL BLK COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT LCK LYN MET MIR924HG MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 SRC TEC TEK TIRAP TP53 TRIM8 TYK2 VAV1 VAV2 YES1	1 interacting genes: SOCS1
Entrez ID		8651	647946
HPRD ID		04669
Ensembl ID		ENSG00000185338	ENSG00000267374
Uniprot IDs		O15524 Q4JHT5
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune System Process Protein Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Phosphorylation Regulation Of Signal Transduction Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process Protein Phosphatase Binding Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of MAPK Cascade Protein Autophosphorylation Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ATP Binding Immune Response-activating Signaling Pathway Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Regulation Of Immune Response Plasma Membrane Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Kinase Inhibitor Activity Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Protein Kinase Inhibitor Activity Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Alpha-beta T Cell Differentiation Macrophage Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Lymphocyte Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Cellular Response To Amino Acid Stimulus Cell Surface Receptor Signaling Pathway Via STAT Insulin-like Growth Factor Receptor Binding Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of T Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Cytokine Receptor Binding Negative Regulation Of Alpha-beta T Cell Activation Response To Amino Acid Negative Regulation Of Hemopoiesis Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Fat Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Myeloid Leukocyte Differentiation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Differentiation Regulation Of T Cell Differentiation Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Regulation Of Lymphocyte Differentiation Myeloid Cell Differentiation Positive Regulation Of T Cell Activation Negative Regulation Of Cell Development
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