SOCS1 and TIRAP

Number of citations of the paper that reports this interaction (PMID 16415872)
109

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SOCS1	TIRAP
Gene Name		suppressor of cytokine signaling 1	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Membrane-bounded Vesicle	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane Intercellular Bridge
	Molecular Function	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Binding, Bridging Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Fat Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Amino Acid Stimulus	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interferon Signaling Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Signaling by SCF-KIT Toll Like Receptor 2 (TLR2) Cascade Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Regulation of KIT signaling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Innate Immune System Growth hormone receptor signaling Adaptive Immune System	Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease and psoriasis ( 22482804) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		40 interactors: ATM AXL COMMD1 CRK CSF1 CSF1R CXCR4 CYTIP EGFR ERBB2 FLT3 FYN GHR GRB2 IFNGR1 IGF1R IL2RB INSR IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 RELA TCEB1 TCEB2 TEC TEK TIRAP TRIM8 VAV1 VAV2	25 interactors: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID		8651	114609
HPRD ID		04669	05878
Ensembl ID		ENSG00000185338	ENSG00000150455
Uniprot IDs		O15524 Q4JHT5	P58753
PDB IDs			2Y92 3UB2 3UB3 3UB4 4FZ5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Protein Autophosphorylation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Response To Stress Phosphatidylinositol-mediated Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Activation Cellular Response To Stimulus Response To Peptide Hormone Cellular Response To Growth Factor Stimulus Signaling Response To Growth Factor Response To Peptide Cell Communication Positive Regulation Of Kinase Activity Response To Stimulus Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway	Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Immune Response Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Biotic Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Other Organism Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Response To Organic Substance Cellular Response To Organic Substance Regulation Of Chemokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Response To External Stimulus Cell Communication Response To Molecule Of Bacterial Origin TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr
Tagcloud (Difference) ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr
Tagcloud (Intersection) ?