Wiki-Pi
About
Search
People
Updates
Search
SOCS1 and MPL
Number of citations of the paper that reports this interaction (PubMedID
29991678
)
28
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
SOCS1
MPL
Description
suppressor of cytokine signaling 1
MPL proto-oncogene, thrombopoietin receptor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Membrane
Neuronal Cell Body
Molecular Function
Protein Kinase Inhibitor Activity
Cytokine Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Kinase Inhibitor Activity
Protein Kinase Binding
Cytokine Receptor Activity
Protein Binding
Thrombopoietin Receptor Activity
Biological Process
Regulation Of Cytokine Production
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Macrophage Differentiation
Developmental Process
Intracellular Signal Transduction
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Fat Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Cellular Response To Amino Acid Stimulus
Neutrophil Homeostasis
Platelet Formation
Monocyte Homeostasis
Thrombopoietin-mediated Signaling Pathway
Positive Regulation Of Lymphocyte Proliferation
Cellular Response To Hypoxia
Positive Regulation Of Platelet Formation
Eosinophil Homeostasis
Basophil Homeostasis
Pathways
Interleukin-7 signaling
Regulation of KIT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Platelet Aggregation (Plug Formation)
Drugs
Romiplostim
SB-559448
Eltrombopag
Thrombopoietin
Avatrombopag
Lusutrombopag
Diseases
Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS
Allergy (
27182965
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
29273806
)
Bulimia nervosa (
23568457
)
Celiac disease (
20190752
)
Crohn's disease (
28067908
)
Crohn's disease and psoriasis (
22482804
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Inflammatory bowel disease (
23128233
28067908
)
Multiple sclerosis (
31604244
)
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Psoriasis (
23143594
)
Psoriasis vulgaris (
26626624
)
Systemic lupus erythematosus (
27399966
26502338
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
54 interacting genes:
AXL
BLK
COMMD1
CRK
CSF1
CSF1R
CUEDC2
CXCR4
CYTIP
EGFR
ELOB
ELOC
ERBB2
ERBB4
FLT3
FYN
GHR
GRB2
IFNAR1
IFNGR1
IGF1R
IL2RB
INSR
IRF7
IRS1
IRS2
ITK
JAK1
JAK2
JAK3
KIT
LCK
LYN
MET
MIR924HG
MPL
NCK1
PDGFRB
PIK3R1
PIK3R2
PIM2
PTK2
RELA
SH3GL1
SRC
TEC
TEK
TIRAP
TP53
TRIM8
TYK2
VAV1
VAV2
YES1
9 interacting genes:
ANKRA2
ATXN2L
IRS2
JAK2
PTPN11
SHC1
SOCS1
THPO
YWHAQ
Entrez ID
8651
4352
HPRD ID
04669
01161
Ensembl ID
ENSG00000185338
ENSG00000117400
Uniprot IDs
O15524
Q4JHT5
P40238
PDB IDs
8G04
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Peptidyl-tyrosine Phosphorylation
Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune System Process
Protein Phosphorylation
Cytokine-mediated Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Activity
Phosphorylation
Regulation Of Signal Transduction
Receptor Complex
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
Protein Phosphatase Binding
Regulation Of Immune System Process
Phosphatidylinositol 3-kinase Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Positive Regulation Of MAPK Cascade
Protein Autophosphorylation
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Growth Hormone Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
ATP Binding
Immune Response-activating Signaling Pathway
Positive Regulation Of Metabolic Process
Phosphotyrosine Residue Binding
Regulation Of Immune Response
Plasma Membrane
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Insulin Receptor Binding
Protein Kinase Binding
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Thrombopoietin-mediated Signaling Pathway
Myeloid Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peptide Hormone Receptor Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Lymphocyte Activation
Phosphatidylinositol 3-kinase Binding
Insulin-like Growth Factor Receptor Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Cell Activation
Cytokine-mediated Signaling Pathway
Peptidyl-tyrosine Dephosphorylation
Positive Regulation Of Hormone Secretion
Megakaryocyte Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of Insulin Secretion
Neuron Projection Regeneration
Hemopoiesis
Regulation Of Lymphocyte Activation
Positive Regulation Of ERK1 And ERK2 Cascade
14-3-3 Protein Binding
Regulation Of Peptide Hormone Secretion
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of D-glucose Import
Epithelial Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Lipid Transport
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of D-glucose Transmembrane Transport
Phosphotyrosine Residue Binding
Regulation Of Mononuclear Cell Proliferation
Regulation Of Cell Activation
Regulation Of Hormone Secretion
Regulation Of Protein Secretion
Positive Regulation Of T Cell Activation
Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Leukocyte Proliferation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of D-glucose Import
Histone H3Y41 Kinase Activity
Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway
Positive Regulation Of Secretion By Cell
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?