SOCS1 and MPL

Number of citations: 28 (PubMedID 29991678)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		SOCS1	MPL
Name		suppressor of cytokine signaling 1	MPL proto-oncogene, thrombopoietin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Membrane Neuronal Cell Body
	Molecular Function	Protein Kinase Inhibitor Activity Cytokine Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding	Cytokine Receptor Activity Protein Binding Thrombopoietin Receptor Activity
	Biological Process	Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Macrophage Differentiation Developmental Process Intracellular Signal Transduction Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus	Neutrophil Homeostasis Platelet Formation Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis
Pathways		Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Platelet Aggregation (Plug Formation)
Drugs		None	Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases		None	Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Allergy ( 27182965 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 31959851 29273806 ) Bulimia nervosa ( 23568457 ) Celiac disease ( 20190752 ) Crohn's disease ( 28067908 ) Crohn's disease and psoriasis ( 22482804 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Inflammatory bowel disease ( 23128233 28067908 ) Multiple sclerosis ( 31604244 ) Primary biliary cholangitis ( 26394269 ) Primary biliary cirrhosis ( 22961000 ) Psoriasis ( 23143594 ) Psoriasis vulgaris ( 26626624 ) Systemic lupus erythematosus ( 27399966 26502338 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		None recorded	1 novel interactors: PTPRF
Interacting Genes		54 interacting genes: AXL BLK COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT LCK LYN MET MIR924HG MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 SRC TEC TEK TIRAP TP53 TRIM8 TYK2 VAV1 VAV2 YES1	9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		8651	4352
HPRD ID		04669	01161
Ensembl ID		ENSG00000185338	ENSG00000117400
Uniprot IDs		O15524 Q4JHT5	P40238
PDB IDs		Not available	8G04
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune System Process Protein Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Phosphorylation Regulation Of Signal Transduction Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process Protein Phosphatase Binding Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of MAPK Cascade Protein Autophosphorylation Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ATP Binding Immune Response-activating Signaling Pathway Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Regulation Of Immune Response Plasma Membrane Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Insulin Receptor Binding Protein Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thrombopoietin-mediated Signaling Pathway Myeloid Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Cell Activation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Hormone Secretion Megakaryocyte Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Insulin Secretion Neuron Projection Regeneration Hemopoiesis Regulation Of Lymphocyte Activation Positive Regulation Of ERK1 And ERK2 Cascade 14-3-3 Protein Binding Regulation Of Peptide Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Import Epithelial Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of T Cell Activation Signal Transduction Regulation Of MAPK Cascade Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of D-glucose Import Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Positive Regulation Of Secretion By Cell