SOCS1 and CSF1

Number of citations of the paper that reports this interaction (PMID 11297560)
5

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SOCS1	CSF1
Gene Name		suppressor of cytokine signaling 1	colony stimulating factor 1 (macrophage)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Membrane-bounded Vesicle	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Fat Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Amino Acid Stimulus	Ossification Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Developmental Process Involved In Reproduction Inflammatory Response Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Hemopoiesis Cell Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organism Growth Monocyte Activation Odontogenesis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interferon Signaling Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Signaling by SCF-KIT Toll Like Receptor 2 (TLR2) Cascade Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Regulation of KIT signaling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Innate Immune System Growth hormone receptor signaling Adaptive Immune System
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease and psoriasis ( 22482804) Inflammatory bowel disease ( 23128233)	Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		40 interactors: ATM AXL COMMD1 CRK CSF1 CSF1R CXCR4 CYTIP EGFR ERBB2 FLT3 FYN GHR GRB2 IFNGR1 IGF1R IL2RB INSR IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 RELA TCEB1 TCEB2 TEC TEK TIRAP TRIM8 VAV1 VAV2	10 interactors: CSF1R FHL3 GAB3 HLA-B NOTCH2NL PIK3R2 SGTA SLA2 SOCS1 TNF
Entrez ID		8651	1435
HPRD ID		04669	00388
Ensembl ID		ENSG00000185338	ENSG00000184371
Uniprot IDs		O15524 Q4JHT5	P09603
PDB IDs			1HMC 3UEZ 3UF2 4ADF 4FA8
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Protein Autophosphorylation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Response To Stress Phosphatidylinositol-mediated Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Activation Cellular Response To Stimulus Response To Peptide Hormone Cellular Response To Growth Factor Stimulus Signaling Response To Growth Factor Response To Peptide Cell Communication Positive Regulation Of Kinase Activity Response To Stimulus Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway	Immune Response Immune System Process Regulation Of Immune Response Myeloid Leukocyte Differentiation Cytokine-mediated Signaling Pathway Macrophage Differentiation Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Response To Cytokine Myeloid Cell Differentiation Positive Regulation Of Chemokine Production Osteoclast Differentiation Innate Immune Response Regulation Of Kinase Activity Regulation Of Chemokine Production Cellular Response To Amino Acid Stimulus Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cytokine Secretion Regulation Of Transcription Factor Import Into Nucleus Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Interleukin-6 Production Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Ketone Metabolic Process Response To Amino Acid Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response
Tagcloud ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1
Tagcloud (Difference) ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1
Tagcloud (Intersection) ?