SOCS1 and TCEB2

Number of citations of the paper that reports this interaction (PMID 10051596)
117

Data Source:
HPRD (in vitro, in vivo)

		SOCS1	TCEB2
Gene Name		suppressor of cytokine signaling 1	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Membrane-bounded Vesicle	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome Elongin Complex
	Molecular Function	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Fat Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Amino Acid Stimulus	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Viral Process Protein Ubiquitination Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interferon Signaling Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Signaling by SCF-KIT Toll Like Receptor 2 (TLR2) Cascade Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Regulation of KIT signaling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Innate Immune System Growth hormone receptor signaling Adaptive Immune System	Vif-mediated degradation of APOBEC3G Formation of HIV-1 elongation complex containing HIV-1 Tat Cellular response to hypoxia RNA Polymerase II Transcription Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Elongation Class I MHC mediated antigen processing & presentation Host Interactions of HIV factors Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome Adaptive Immune System RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease and psoriasis ( 22482804) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		40 interactors: ATM AXL COMMD1 CRK CSF1 CSF1R CXCR4 CYTIP EGFR ERBB2 FLT3 FYN GHR GRB2 IFNGR1 IGF1R IL2RB INSR IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 RELA TCEB1 TCEB2 TEC TEK TIRAP TRIM8 VAV1 VAV2	17 interactors: ASB2 ASB8 CEBPE CUL5 GNB2L1 LRRC41 PRAME RNF7 SOCS1 SOCS3 SOCS6 TCEB1 TCEB3 TCEB3B TCEB3C VHL ZYG11B
Entrez ID		8651	6923
HPRD ID		04669	02874
Ensembl ID		ENSG00000185338	ENSG00000103363
Uniprot IDs		O15524 Q4JHT5	Q15370
PDB IDs			1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 3DCG 3ZKJ 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Protein Autophosphorylation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Response To Stress Phosphatidylinositol-mediated Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Activation Cellular Response To Stimulus Response To Peptide Hormone Cellular Response To Growth Factor Stimulus Signaling Response To Growth Factor Response To Peptide Cell Communication Positive Regulation Of Kinase Activity Response To Stimulus Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of JAK-STAT Cascade Protein Metabolic Process JAK-STAT Cascade Negative Regulation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Kinase Activity Cellular Metabolic Process Regulation Of JAK-STAT Cascade Regulation Of Growth Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Intracellular Signal Transduction Negative Regulation Of Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Metabolic Process Regulation Of Cellular Process Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Negative Regulation Of Cell Death Regulation Of Type I Interferon-mediated Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Viral Transcription Cellular Protein Catabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Signaling Response To Stress Transcription Elongation From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase Activity Cellular Response To Peptide Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2
Tagcloud (Difference) ?		1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597	100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2
Tagcloud (Intersection) ?