RUNX2 and SMAD6

Number of citations: 40 (PubMedID 16299379)
Data Source: HPRD (in vitro)

		RUNX2	SMAD6
Name		RUNX family transcription factor 2	SMAD family member 6
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Cilium Nuclear Body Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding Chromatin DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Activin Receptor Binding Type I Activin Receptor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Regulation Of Ossification Bone Mineralization BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Ligamentous Ossification Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Stem Cell Proliferation Response To Sodium Phosphate Positive Regulation Of Stem Cell Proliferation	Ureteric Bud Development Outflow Tract Septum Morphogenesis Heart Valve Development Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Negative Regulation Of Activin Receptor Signaling Pathway Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Coronary Vasculature Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of MiRNA Transcription
Pathways		None	Signaling by BMP RUNX2 regulates bone development
Diseases		Cleidocranial dysplasia	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Central corneal thickness ( 32528159 29760442 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) facial morphology traits (multivariate analysis) ( 27193062 ) Gout (normal type) ( 32238385 ) Height ( 18391951 25429064 ) Hip minimal joint space width ( 27701424 ) Hip shape (DXA scan) ( 30320955 ) Intraocular pressure ( 29785010 30054594 ) Itch intensity from mosquito bite ( 28199695 ) LDL cholesterol levels in HIV infection ( 33109212 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 ) Mosquito bite size ( 28199695 ) Osteoarthritis (hip) ( 30374069 ) Periodontal microbiota ( 22699663 ) Progressive supranuclear palsy ( 30089514 ) Relative brain age ( 34098431 ) Subcortical volume (MOSTest) ( 32665545 ) Survival in pancreatic cancer ( 28470677 ) Youthful appearance (self-reported) ( 32339537 )	Appendicular lean mass ( 33097823 ) Asthma ( 29273806 31959851 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Carpal tunnel syndrome ( 30833571 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Glaucoma (primary open-angle) ( 33627673 ) Height ( 31562340 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Lung cancer (smoking interaction) ( 24658283 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Severe aortic features in Marfan syndrome ( 30087447 ) Subcutaneous adipose tissue ( 22589738 ) Waist-hip ratio ( 25673412 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 )
Novel Interactors		1 novel interactors: PRIM2	7 novel interactors: ANXA2 MYO1E PIGB PIK3R4 PPIB RAB11A UACA
Interacting Genes		41 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DTX2 DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HES1 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PIN1 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF USP24 XRCC5 XRCC6 YAP1	17 interacting genes: BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1
Entrez ID		860	4091
HPRD ID		02566	04240
Ensembl ID		ENSG00000124813	ENSG00000137834
Uniprot IDs		A0A0D9SEN7 Q13950 Q32MY8	O43541
PDB IDs		6VG8 6VGD 6VGE 6VGG	Not available
GO Terms Enriched among Interactors		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Differentiation Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cell Differentiation Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process R-SMAD Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of MiRNA Transcription Chromatin DNA-templated Transcription Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of MiRNA Metabolic Process	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process BMP Signaling Pathway SMAD Protein Signal Transduction Osteoblast Fate Commitment Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Activin Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Protein Kinase Activity Transferase Activity Heteromeric SMAD Protein Complex Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction Protein-containing Complex Regulation Of Metabolic Process Response To Growth Factor Intracellular Signal Transduction Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process