SMAD6 and MYO1E

		SMAD6	MYO1E
Description		SMAD family member 6	myosin IE
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Cilium Nuclear Body Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex	Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Adherens Junction Actin Cytoskeleton Myosin Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Activin Receptor Binding Type I Activin Receptor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Lipid Binding ATP Hydrolysis Activity Phosphatidylinositol Binding Actin Filament Binding
	Biological Process	Ureteric Bud Development Outflow Tract Septum Morphogenesis Heart Valve Development Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Negative Regulation Of Activin Receptor Signaling Pathway Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Coronary Vasculature Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of MiRNA Transcription	Vasculogenesis In Utero Embryonic Development Kidney Development Glomerular Filtration Endocytosis Actin Filament Organization Hemopoiesis Glomerulus Development Glomerular Basement Membrane Development Post-embryonic Hemopoiesis Platelet-derived Growth Factor Receptor Signaling Pathway Podocyte Development
Pathways		Signaling by BMP RUNX2 regulates bone development
Drugs			Imidazole
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 29273806 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Adult body size ( 32376654) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 22916037) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Serum metabolite levels (CMS) ( 31636271) Social communication problems ( 24047820)
Interacting Genes		17 interacting genes: BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1	7 interacting genes: ACTB CLIC6 CREBBP LTB4R2 PDE4B RIPK4 SRPK2
Entrez ID		4091	4643
HPRD ID		04240	03281
Ensembl ID		ENSG00000137834	ENSG00000157483
Uniprot IDs		O43541	Q12965 Q4KMR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process BMP Signaling Pathway SMAD Protein Signal Transduction Osteoblast Fate Commitment Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Activin Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Protein Kinase Activity Transferase Activity Heteromeric SMAD Protein Complex Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction Protein-containing Complex Regulation Of Metabolic Process Response To Growth Factor Intracellular Signal Transduction Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process	Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Zygotic Specification Of Dorsal/ventral Axis Type I Activin Receptor Binding Negative Regulation Of Relaxation Of Cardiac Muscle D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body MRF Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Nuclear Speck Organization Leukotriene Signaling Pathway Chromatin Remodeling Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Morphogenesis Of A Polarized Epithelium Activin Receptor Binding Regulation Of Relaxation Of Cardiac Muscle Keratinocyte Migration Structural Constituent Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Relaxation Of Muscle Positive Regulation Of Biosynthetic Process
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