SMAD6 and STAMBP

Number of citations of the paper that reports this interaction (PMID 11483516)
21

Data Source:
HPRD (in vivo, two hybrid)

		SMAD6	STAMBP
Gene Name		SMAD family member 6	STAM binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Cytosol Protein Complex	Nucleus Nucleoplasm Cytoplasm Early Endosome Plasma Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding	Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	Ureteric Bud Development Transcription, DNA-templated Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Proliferation Negative Regulation Of SMAD Protein Complex Assembly BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Laminar Fluid Shear Stress Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Mitotic Cytokinesis Proteolysis JAK-STAT Cascade Positive Regulation Of Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		16 interactors: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1	39 interactors: ALAS1 AMN BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 ITGA5 MAP2K5 MAP3K2 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SPG7 STAM STAM2 TNFRSF1A TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28
Entrez ID		4091	10617
HPRD ID		04240	05877
Ensembl ID		ENSG00000137834	ENSG00000124356
Uniprot IDs		O43541	O95630
PDB IDs			2XZE 3RZU 3RZV
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor BMP Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Organic Substance Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Regulation Of Ossification Regulation Of Cartilage Development MAPK Cascade Cellular Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Metaphase Plate Congression Vacuolar Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Endosomal Transport Regulation Of Centrosome Cycle Mitotic Sister Chromatid Segregation Mitotic Nuclear Division Sister Chromatid Segregation Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Nucleus Organization Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Cycle Process Intracellular Transport Membrane Organization Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Viral Process Negative Regulation Of ERBB Signaling Pathway Protein Transport Mitotic Cell Cycle Viral Life Cycle Establishment Of Localization In Cell Establishment Of Protein Localization Regulation Of Mitotic Nuclear Division Regulation Of Protein Complex Assembly Regulation Of Viral Release From Host Cell Cellular Localization Virion Assembly Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Viral Budding Via Host ESCRT Complex Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Signaling Viral Budding Intracellular Signal Transduction Establishment Of Organelle Localization Regulation Of Cell Cycle Process Regulation Of Cytoskeleton Organization
Tagcloud ?		5fu annotation anticancer array chemoresistance concluded consequently deacetylases deacetylation downregulate fluorouracil fu hdac4 hdac4mediated hdac4oe hdacs mb mcf7 mda morphogenetic overexpressing remodeling restored smad4 stably summary tgfbeta2 transforming verify
Tagcloud (Difference) ?		5fu annotation anticancer array chemoresistance concluded consequently deacetylases deacetylation downregulate fluorouracil fu hdac4 hdac4mediated hdac4oe hdacs mb mcf7 mda morphogenetic overexpressing remodeling restored smad4 stably summary tgfbeta2 transforming verify
Tagcloud (Intersection) ?