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SMAD6 and STAMBP
Number of citations of the paper that reports this interaction (PubMedID
11483516
)
50
Data Source:
HPRD
(two hybrid, in vivo)
SMAD6
STAMBP
Description
SMAD family member 6
STAM binding protein
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Golgi Apparatus
Cytosol
Cilium
Nuclear Body
Protein-containing Complex
Ciliary Basal Body
Heteromeric SMAD Protein Complex
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Membrane
Cleavage Furrow
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
Chromatin Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Activin Receptor Binding
Type I Activin Receptor Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Hydrolase Activity
Protein Domain Specific Binding
Metal Ion Binding
K63-linked Deubiquitinase Activity
Deubiquitinase Activity
Metal-dependent Deubiquitinase Activity
Biological Process
Ureteric Bud Development
Outflow Tract Septum Morphogenesis
Heart Valve Development
Aortic Valve Morphogenesis
Mitral Valve Morphogenesis
Pulmonary Valve Morphogenesis
Ventricular Septum Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Immune Response
Zygotic Specification Of Dorsal/ventral Axis
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Cell Differentiation
Negative Regulation Of Ossification
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Cell-substrate Adhesion
Response To Lipopolysaccharide
Negative Regulation Of Activin Receptor Signaling Pathway
Response To Laminar Fluid Shear Stress
Aorta Development
Negative Regulation Of Apoptotic Process
Response To Estrogen
Fat Cell Differentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Coronary Vasculature Development
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of MiRNA Transcription
Mitotic Cytokinesis
Proteolysis
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Protein Deubiquitination
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein K63-linked Deubiquitination
Hippocampal Neuron Apoptotic Process
Negative Regulation Of Hippocampal Neuron Apoptotic Process
Pathways
Signaling by BMP
RUNX2 regulates bone development
Metalloprotease DUBs
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Carpal tunnel syndrome (
30833571
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Glaucoma (primary open-angle) (
33627673
)
Height (
31562340
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Hip circumference adjusted for BMI (
34021172
)
Lung cancer (smoking interaction) (
24658283
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Refractive error (
32231278
)
Severe aortic features in Marfan syndrome (
30087447
)
Subcutaneous adipose tissue (
22589738
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Anti-saccade response (
29064472
)
Bell's palsy (
33602968
)
Blood metabolite levels (
26401656
)
Serum metabolite levels (
23093944
33031748
)
Interacting Genes
17 interacting genes:
BMPR1B
CHRM5
HOXC8
MAP3K7
MAPK6
RNF111
RPS6KA5
RUNX2
SMAD1
SMAD7
SMURF1
SMURF2
STAMBP
STRAP
TAB1
TGFBR1
TOB1
51 interacting genes:
ALAS1
AMN
APOBEC3A
ATG14
BMPR1B
CASR
CHMP1A
CHMP1B
CHMP2A
CHMP3
CHMP4A
CHMP4B
CHMP4C
CHMP5
CLTC
CTNNBL1
CYP2C9
DSCR9
EGFR
EPS15
GRAP2
GRB2
IL1RL2
ITGA5
MAP2K5
MAP3K2
MLKL
NLRP7
NTPCR
PJA1
RBM11
RECQL5
RNF11
SMAD2
SMAD6
SMAD7
SNCA
SPG7
STAM
STAM2
TNFRSF1A
TP53
TRAF6
TRIP13
UACA
UBC
UBE2S
ULK1
USP21
USP28
VHL
Entrez ID
4091
10617
HPRD ID
04240
05877
Ensembl ID
ENSG00000137834
ENSG00000124356
Uniprot IDs
O43541
A0A140VK54
A0A804HIF8
A0A804HII8
A0A804HJ64
O95630
PDB IDs
2XZE
3RZU
3RZV
5IXF
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
SMAD Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
I-SMAD Binding
Regulation Of Cartilage Development
Positive Regulation Of Cartilage Development
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Chondrocyte Differentiation
Negative Regulation Of BMP Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
BMP Signaling Pathway
SMAD Protein Signal Transduction
Osteoblast Fate Commitment
Regulation Of Signaling
Negative Regulation Of Signal Transduction
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Signal Transduction
Negative Regulation Of Chondrocyte Proliferation
Transforming Growth Factor Beta Receptor Activity, Type I
Regulation Of BMP Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Activin Receptor Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Multicellular Organismal Process
Regulation Of Cell Communication
Positive Regulation Of Developmental Process
Regulation Of Osteoblast Differentiation
Protein Kinase Activity
Transferase Activity
Heteromeric SMAD Protein Complex
Positive Regulation Of CGAS/STING Signaling Pathway
Regulation Of Signal Transduction
Protein-containing Complex
Regulation Of Metabolic Process
Response To Growth Factor
Intracellular Signal Transduction
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Macromolecule Metabolic Process
Protein Phosphorylation
Regulation Of Primary Metabolic Process
ESCRT III Complex
Amphisome Membrane
Vesicle Fusion With Vacuole
Multivesicular Body Organization
Multivesicular Body Assembly
Multivesicular Body-lysosome Fusion
Viral Budding From Plasma Membrane
Late Endosome To Vacuole Transport
Lysosomal Membrane Organization
Endosome Transport Via Multivesicular Body Sorting Pathway
Membrane Fission
Multivesicular Body Sorting Pathway
Late Endosome To Lysosome Transport
Kinetochore Microtubule
Autophagosome Membrane
Viral Budding Via Host ESCRT Complex
Regulation Of Mitotic Spindle Assembly
Midbody Abscission
Regulation Of Mitotic Spindle Organization
Viral Budding
Nuclear Membrane Reassembly
Mitotic Cytokinetic Process
Multivesicular Body Membrane
Viral Release From Host Cell
Plasma Membrane Repair
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Autophagosome Maturation
Endosome Organization
Regulation Of Spindle Assembly
Autophagy
Cytokinetic Process
Protein-containing Complex Disassembly
Endosomal Transport
Multivesicular Body
Mitotic Metaphase Chromosome Alignment
Biological Process Involved In Interaction With Host
Nuclear Membrane Organization
Vacuolar Transport
Vacuole Organization
Metaphase Chromosome Alignment
Membrane Assembly
Endosome
Macroautophagy
Regulation Of Microtubule Cytoskeleton Organization
Chromosome Localization
Lysosomal Transport
Regulation Of Centrosome Duplication
Nuclear Pore
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Nucleus Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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