RUNX2 and XRCC5

Number of citations of the paper that reports this interaction (PubMedID 12145311)
0

Data Source:
HPRD (in vitro)

		RUNX2	XRCC5
Description		RUNX family transcription factor 2	X-ray repair cross complementing 5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding Chromatin DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Regulation Of Ossification Bone Mineralization BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Ligamentous Ossification Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Stem Cell Proliferation Response To Sodium Phosphate Positive Regulation Of Stem Cell Proliferation	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Biosynthetic Process Neurogenesis Regulation Of Telomere Maintenance Small-subunit Processome Assembly Ribosome Biogenesis Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Hematopoietic Stem Cell Proliferation Cellular Response To Gamma Radiation Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor
Pathways			2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases		Cleidocranial dysplasia
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) facial morphology traits (multivariate analysis) ( 27193062) Gout (normal type) ( 32238385) Height ( 18391951 25429064) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Relative brain age ( 34098431) Subcortical volume (MOSTest) ( 32665545) Survival in pancreatic cancer ( 28470677) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		41 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DTX2 DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HES1 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PIN1 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF USP24 XRCC5 XRCC6 YAP1	59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DEAF1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A
Entrez ID		860	7520
HPRD ID		02566	08935
Ensembl ID		ENSG00000124813	ENSG00000079246
Uniprot IDs		A0A0D9SEN7 Q13950 Q32MY8	P13010
PDB IDs		6VG8 6VGD 6VGE 6VGG	1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE 7AXZ 7K0Y 7K17 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7SUD 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Differentiation Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cell Differentiation Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process R-SMAD Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of MiRNA Transcription Chromatin DNA-templated Transcription Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of MiRNA Metabolic Process	DNA Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Positive Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Telomere Maintenance Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Response To Gamma Radiation Regulation Of RNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Macromolecule Biosynthetic Process Telomere Organization Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Replication Regulation Of Double-strand Break Repair Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromosome Organization Positive Regulation Of DNA-templated Transcription DNA Recombination Negative Regulation Of DNA Metabolic Process DNA Strand Elongation Regulation Of Gene Expression Recombinational Repair Response To Ionizing Radiation
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