SMAD6 and SMURF2

  • Number of citations of the paper that reports this interaction (PMID 15761153)
  • 154
  • Data Source:
  • BioGRID (two hybrid, affinity chromatography technology)
  • HPRD (in vivo, two hybrid)

SMAD6

SMURF2

Gene Name SMAD family member 6 SMAD specific E3 ubiquitin protein ligase 2
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions 16 interactors: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1 79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44
Entrez ID 4091 64750
HPRD ID 04240 06901
Ensembl ID ENSG00000137834
Uniprot IDs O43541 Q96DE7 Q9HAU4
PDB IDs 1ZVD 2DJY 2JQZ 2KXQ 2LTZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
5fu  annotation  anticancer  array  chemoresistance  concluded  consequently  deacetylases  deacetylation  downregulate  fluorouracil  fu  hdac4  hdac4mediated  hdac4oe  hdacs  mb  mcf7  mda  morphogenetic  overexpressing  remodeling  restored  smad4  stably  summary  tgfbeta2  transforming  verify 
autoinhibitory  biochemical  c2  catalytic  controlled  domain  dysregulation  e3  e3s  framework  hect  impaired  interaction  intramolecular  ligases  magnetic  maintaining  nedd4  nmr  noncovalent  regulate  regulators  resonance  state  structural  terminal  transthiolation  ub  ubiquitin 
Tagcloud (Difference) ?
5fu  annotation  anticancer  array  chemoresistance  concluded  consequently  deacetylases  deacetylation  downregulate  fluorouracil  fu  hdac4  hdac4mediated  hdac4oe  hdacs  mb  mcf7  mda  morphogenetic  overexpressing  remodeling  restored  smad4  stably  summary  tgfbeta2  transforming  verify 
autoinhibitory  biochemical  c2  catalytic  controlled  domain  dysregulation  e3  e3s  framework  hect  impaired  interaction  intramolecular  ligases  magnetic  maintaining  nedd4  nmr  noncovalent  regulate  regulators  resonance  state  structural  terminal  transthiolation  ub  ubiquitin 
Tagcloud (Intersection) ?