RUNX2 and KAT6B

Number of citations of the paper that reports this interaction (PubMedID 11965546)
0

Data Source:
HPRD (in vitro, in vivo)

		RUNX2	KAT6B
Description		RUNX family transcription factor 2	lysine acetyltransferase 6B
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Chromatin Nucleosome Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding Chromatin DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Protein-containing Complex Binding Metal Ion Binding Protein-lysine-acetyltransferase Activity
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Regulation Of Ossification Bone Mineralization BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Ligamentous Ossification Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Stem Cell Proliferation Response To Sodium Phosphate Positive Regulation Of Stem Cell Proliferation	Chromatin Organization Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process Regulation Of Hemopoiesis
Pathways			HATs acetylate histones
Drugs
Diseases		Cleidocranial dysplasia
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) facial morphology traits (multivariate analysis) ( 27193062) Gout (normal type) ( 32238385) Height ( 18391951 25429064) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Relative brain age ( 34098431) Subcortical volume (MOSTest) ( 32665545) Survival in pancreatic cancer ( 28470677) Youthful appearance (self-reported) ( 32339537)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		41 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DTX2 DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HES1 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PIN1 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF USP24 XRCC5 XRCC6 YAP1	5 interacting genes: ATN1 H3C1 RUNX1 RUNX2 UBE2I
Entrez ID		860	23522
HPRD ID		02566	07065
Ensembl ID		ENSG00000124813	ENSG00000156650
Uniprot IDs		A0A0D9SEN7 Q13950 Q32MY8	B2RWN8 Q8WYB5
PDB IDs		6VG8 6VGD 6VGE 6VGG	5U2J 6OIE 8E4V
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Differentiation Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cell Differentiation Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process R-SMAD Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of MiRNA Transcription Chromatin DNA-templated Transcription Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of MiRNA Metabolic Process	Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chondrocyte Differentiation Negative Regulation Of Biosynthetic Process Ligamentous Ossification Stem Cell Proliferation SUMO Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Ossification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Osteoblast Fate Commitment Regulation Of RNA Biosynthetic Process Core-binding Factor Complex RING-like Zinc Finger Domain Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Hemopoiesis Regulation Of Metabolic Process Cell Population Proliferation Cardiac Muscle Tissue Regeneration Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding G1 To G0 Transition Involved In Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Nucleus Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Nucleoplasm Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Sodium Phosphate Negative Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Negative Regulation Of Granulocyte Differentiation Mitotic Nuclear Membrane Reassembly Peripheral Nervous System Neuron Development Gene Expression Transferase Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Connective Tissue Replacement
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