RUNX2 and KAT6B

Number of citations of the paper that reports this interaction (PMID 11965546)
21

Data Source:
HPRD (in vitro, in vivo)

		RUNX2	KAT6B
Gene Name		runt-related transcription factor 2	K(lysine) acetyltransferase 6B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleosome Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Repressing Transcription Factor Binding	DNA Binding Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity
	Biological Process	Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Development Osteoblast Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Acetylation Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Height ( 18391951) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		36 interactors: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1	4 interactors: ATN1 RUNX1 RUNX2 SUMO1
Entrez ID		860	23522
HPRD ID		02566	07065
Ensembl ID		ENSG00000124813	ENSG00000156650
Uniprot IDs		F8W8U5 Q13950 Q32MY8	B2RWN8 Q8WYB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Organ Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Metabolic Process Cellular Response To Stimulus Tissue Development Cellular Response To Stress System Development Regulation Of Cell Differentiation Response To Growth Factor Developmental Process Heart Development Positive Regulation Of Cell Differentiation Cardiovascular System Development Cell Differentiation Negative Regulation Of Signal Transduction	Positive Regulation Of Progesterone Secretion Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Progesterone Secretion PML Body Organization Regulation Of Hair Follicle Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Localization To Nuclear Pore Protein Localization To Nuclear Envelope Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Granulocyte Differentiation Regulation Of RNA Metabolic Process Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Response To Organic Substance Anatomical Structure Development Osteoblast Fate Commitment Peripheral Nervous System Neuron Development Regulation Of Female Gonad Development Maintenance Of Cell Polarity Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Toxin Metabolic Process Embryonic Organ Development Hematopoietic Stem Cell Proliferation Negative Regulation Of Cellular Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth Immune System Process Developmental Process Nitrogen Compound Metabolic Process Skeletal System Development Transcription, DNA-templated Cellular Response To Growth Factor Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Behavioral Response To Pain Response To Growth Factor Regulation Of Response To Interferon-gamma RNA Biosynthetic Process Definitive Hemopoiesis Hemopoiesis Protein Sumoylation
Tagcloud ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated	acetal applying arises brca1 brca2 carrier clustering coding damaging decade detects dispositions entire exome exons familial families focusing germline identifying nonsynonymous obligate predisposition sanger sequenced spite transferase unaffected variants
Tagcloud (Difference) ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated	acetal applying arises brca1 brca2 carrier clustering coding damaging decade detects dispositions entire exome exons familial families focusing germline identifying nonsynonymous obligate predisposition sanger sequenced spite transferase unaffected variants
Tagcloud (Intersection) ?