SMAD6 and TGFBR1

Number of citations of the paper that reports this interaction (PMID 9335505)
137

Data Source:
HPRD (in vivo, in vitro)

		SMAD6	TGFBR1
Gene Name		SMAD family member 6	transforming growth factor, beta receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Cytosol Protein Complex	Cell Endosome Plasma Membrane Tight Junction Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Receptor Signaling Protein Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Growth Factor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding I-SMAD Binding
	Biological Process	Ureteric Bud Development Transcription, DNA-templated Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Proliferation Negative Regulation Of SMAD Protein Complex Assembly BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Laminar Fluid Shear Stress Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Activation Of MAPKK Activity Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Palate Development Pharyngeal System Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Response To Cholesterol Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by BMP	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)	Age-related macular degeneration ( 23455636) Dental caries ( 23064961)
Protein-Protein Interactions		16 interactors: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1	159 interactors: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K7 MYO3A MYOC NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP4 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZAK ZFYVE9
Entrez ID		4091	7046
HPRD ID		04240	01822
Ensembl ID		ENSG00000137834	ENSG00000106799
Uniprot IDs		O43541	P36897 Q5T7S2
PDB IDs			1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor BMP Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Organic Substance Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Regulation Of Ossification Regulation Of Cartilage Development MAPK Cascade Cellular Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signal Transduction Response To Transforming Growth Factor Beta Signal Transduction Cell Communication Signaling Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Cellular Response To Stimulus Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Modification Process Regulation Of Signaling Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Organic Substance Protein Phosphorylation Phosphorylation Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Process Signal Transduction By Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Morphogenesis SMAD Protein Complex Assembly Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?		5fu annotation anticancer array chemoresistance concluded consequently deacetylases deacetylation downregulate fluorouracil fu hdac4 hdac4mediated hdac4oe hdacs mb mcf7 mda morphogenetic overexpressing remodeling restored smad4 stably summary tgfbeta2 transforming verify	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		5fu annotation anticancer array chemoresistance concluded consequently deacetylases deacetylation downregulate fluorouracil fu hdac4 hdac4mediated hdac4oe hdacs mb mcf7 mda morphogenetic overexpressing remodeling restored smad4 stably summary tgfbeta2 transforming verify	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?