RUNX2 and HDAC4

  • Number of citations of the paper that reports this interaction (PMID 15537544)
  • 156
  • Data Source:
  • HPRD (in vivo, in vitro)

RUNX2

HDAC4

Gene Name runt-related transcription factor 2 histone deacetylase 4
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
  • Male-pattern baldness ( 22693459)
  • Pulmonary function ( 21946350)
  • Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions 36 interactors: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1 89 interactors: ACTA1 ANKRA2 ANKRD11 APP AR ATF3 ATRX BCL6 BCOR BRMS1 CACNA1C CAMK2D CAMK4 CBX5 CCDC136 CDKN1A CDR2 CEBPD CIITA CSRP3 CTBP1 EFEMP2 ESR1 GATA1 GCM1 GNB1 GOLGA2 GSK3B HDAC3 HDAC7 HDAC9 HNF4A IFRD1 IKZF2 JDP2 KRT31 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBIE NPPB NR1H2 NR2C1 NR2C2 NUP155 PNMA1 PPARD PPARG PPP2R4 RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SUMO1 SUMO2 SYK TNFRSF14 UBE2I YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZNF354A
Entrez ID 860 9759
HPRD ID 02566 05610
Ensembl ID ENSG00000124813 ENSG00000068024
Uniprot IDs F8W8U5 Q13950 Q32MY8 B7Z8G5 P56524 Q86YH7
PDB IDs 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31
Enriched GO Terms of Interacting Partners?
Tagcloud ?
1q22  aml  correlative  cytogenetic  decitabine  demethylating  elucidate  epigenetics  frequent  haematological  hypermethylation  inactivation  inv  leukaemia  leukaemias  lymphocytic  malignancies  methylated  mostly  myelodysplatic  p13  promoters  re  relapse  runx1  runx3  syndromes  unmethylated 
300mg  50mg  ameliorated  ameliorates  ctgf  dawley  deacetylases  dn  emphasize  fibrogenesis  fibronectin  fibrosis  fibrotic  hdacs  histology  icam  microscope  migraine  myofibroblast  nephropathy  profibrotic  renoprotective  route  sma  sprague  stz  valproic  vpa 
Tagcloud (Difference) ?
1q22  aml  correlative  cytogenetic  decitabine  demethylating  elucidate  epigenetics  frequent  haematological  hypermethylation  inactivation  inv  leukaemia  leukaemias  lymphocytic  malignancies  methylated  mostly  myelodysplatic  p13  promoters  re  relapse  runx1  runx3  syndromes  unmethylated 
300mg  50mg  ameliorated  ameliorates  ctgf  dawley  deacetylases  dn  emphasize  fibrogenesis  fibronectin  fibrosis  fibrotic  hdacs  histology  icam  microscope  migraine  myofibroblast  nephropathy  profibrotic  renoprotective  route  sma  sprague  stz  valproic  vpa 
Tagcloud (Intersection) ?