SMAD6 and RUNX2

Number of citations of the paper that reports this interaction (PMID 16299379)
32

Data Source:
HPRD (in vitro)

		SMAD6	RUNX2
Gene Name		SMAD family member 6	runt-related transcription factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Cytosol Protein Complex	Nuclear Chromatin Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Repressing Transcription Factor Binding
	Biological Process	Ureteric Bud Development Transcription, DNA-templated Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Proliferation Negative Regulation Of SMAD Protein Complex Assembly BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Laminar Fluid Shear Stress Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Development Osteoblast Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Signaling by BMP	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)	Height ( 18391951) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		16 interactors: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1	36 interactors: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1
Entrez ID		4091	860
HPRD ID		04240	02566
Ensembl ID		ENSG00000137834	ENSG00000124813
Uniprot IDs		O43541	F8W8U5 Q13950 Q32MY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor BMP Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Organic Substance Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Regulation Of Ossification Regulation Of Cartilage Development MAPK Cascade Cellular Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Organ Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Metabolic Process Cellular Response To Stimulus Tissue Development Cellular Response To Stress System Development Regulation Of Cell Differentiation Response To Growth Factor Developmental Process Heart Development Positive Regulation Of Cell Differentiation Cardiovascular System Development Cell Differentiation Negative Regulation Of Signal Transduction
Tagcloud ?		5fu annotation anticancer array chemoresistance concluded consequently deacetylases deacetylation downregulate fluorouracil fu hdac4 hdac4mediated hdac4oe hdacs mb mcf7 mda morphogenetic overexpressing remodeling restored smad4 stably summary tgfbeta2 transforming verify	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated
Tagcloud (Difference) ?		5fu annotation anticancer array chemoresistance concluded consequently deacetylases deacetylation downregulate fluorouracil fu hdac4 hdac4mediated hdac4oe hdacs mb mcf7 mda morphogenetic overexpressing remodeling restored smad4 stably summary tgfbeta2 transforming verify	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated
Tagcloud (Intersection) ?