RUNX2 and HIVEP3

Number of citations of the paper that reports this interaction (PubMedID 16728642)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RUNX2	HIVEP3
Description		RUNX family transcription factor 2	HIVEP zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding Chromatin DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Regulation Of Ossification Bone Mineralization BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Ligamentous Ossification Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Stem Cell Proliferation Response To Sodium Phosphate Positive Regulation Of Stem Cell Proliferation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases		Cleidocranial dysplasia
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) facial morphology traits (multivariate analysis) ( 27193062) Gout (normal type) ( 32238385) Height ( 18391951 25429064) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Relative brain age ( 34098431) Subcortical volume (MOSTest) ( 32665545) Survival in pancreatic cancer ( 28470677) Youthful appearance (self-reported) ( 32339537)	Adult body size ( 32376654) Airway imaging phenotypes ( 26030696) Breast cancer ( 29059683) Bronchopulmonary dysplasia ( 23897914) Diastolic blood pressure ( 27618452) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) Heel bone mineral density ( 30598549) High myopia ( 32428537) Intraocular pressure ( 29235454) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lupus nephritis in systemic lupus erythematosus ( 24925725) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418 27841878) Refractive error ( 32231278) Spatial memory ( 31596458) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418 27841878 27618452) Treatment resistant depression ( 30468137) White blood cell count ( 32888494)
Interacting Genes		41 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DTX2 DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HES1 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PIN1 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF USP24 XRCC5 XRCC6 YAP1	6 interacting genes: FHL1 GRSF1 RUNX2 TNFRSF1B TRAF1 TRAF2
Entrez ID		860	59269
HPRD ID		02566	09442
Ensembl ID		ENSG00000124813	ENSG00000127124
Uniprot IDs		A0A0D9SEN7 Q13950 Q32MY8	Q5T1R4
PDB IDs		6VG8 6VGD 6VGE 6VGG
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Differentiation Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cell Differentiation Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process R-SMAD Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of MiRNA Transcription Chromatin DNA-templated Transcription Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of MiRNA Metabolic Process	Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex Tumor Necrosis Factor Binding Thioesterase Binding Tumor Necrosis Factor Receptor Binding Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Binding Ligamentous Ossification Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TORC2 Complex Disassembly Regulation Of T Cell Mediated Immunity Positive Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Cytokine Production Involved In Immune Response Osteoblast Fate Commitment Positive Regulation Of Mitochondrial RNA Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Channel Activator Activity Potassium Channel Activator Activity Mitochondrial RNA Catabolic Process Membrane Raft Apoptotic Process Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Apoptotic Process Involved In Morphogenesis Negative Regulation Of Extracellular Matrix Constituent Secretion Aortic Valve Development Regulation Of RNA Stability Pulmonary Valve Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Intrinsic Apoptotic Signaling Pathway Glial Cell-neuron Signaling Regulation Of Lymphocyte Mediated Immunity Semi-lunar Valve Development Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Sphingolipid Binding IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding G-quadruplex RNA Binding Cell Death Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion
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