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SMAD6 and SMURF1
Number of citations of the paper that reports this interaction (PubMedID
11278251
)
0
Data Source:
HPRD
(in vivo)
SMAD6
SMURF1
Description
SMAD family member 6
SMAD specific E3 ubiquitin protein ligase 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Golgi Apparatus
Cytosol
Cilium
Nuclear Body
Protein-containing Complex
Ciliary Basal Body
Heteromeric SMAD Protein Complex
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Membrane
Axon
Neuronal Cell Body
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
Chromatin Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Activin Receptor Binding
Type I Activin Receptor Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Ubiquitin-protein Transferase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phospholipid Binding
Transferase Activity
SMAD Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
Activin Receptor Binding
Biological Process
Ureteric Bud Development
Outflow Tract Septum Morphogenesis
Heart Valve Development
Aortic Valve Morphogenesis
Mitral Valve Morphogenesis
Pulmonary Valve Morphogenesis
Ventricular Septum Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Immune Response
Zygotic Specification Of Dorsal/ventral Axis
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Cell Differentiation
Negative Regulation Of Ossification
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Cell-substrate Adhesion
Response To Lipopolysaccharide
Negative Regulation Of Activin Receptor Signaling Pathway
Response To Laminar Fluid Shear Stress
Aorta Development
Negative Regulation Of Apoptotic Process
Response To Estrogen
Fat Cell Differentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Coronary Vasculature Development
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of MiRNA Transcription
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Export From Nucleus
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Receptor Catabolic Process
Negative Regulation Of Activin Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Axon Extension
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Engulfment Of Target By Autophagosome
Substrate Localization To Autophagosome
Protein Targeting To Vacuole Involved In Autophagy
Protein Localization To Plasma Membrane
Positive Regulation Of Dendrite Extension
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Signaling by BMP
RUNX2 regulates bone development
Signaling by BMP
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog 'on' state
Hedgehog 'on' state
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Carpal tunnel syndrome (
30833571
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Glaucoma (primary open-angle) (
33627673
)
Height (
31562340
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Hip circumference adjusted for BMI (
34021172
)
Lung cancer (smoking interaction) (
24658283
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Refractive error (
32231278
)
Severe aortic features in Marfan syndrome (
30087447
)
Subcutaneous adipose tissue (
22589738
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Facial emotion recognition (sad faces) (
28608620
)
Inflammatory bowel disease (
23128233
28067908
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Ulcerative colitis (
20228798
28067908
)
Interacting Genes
17 interacting genes:
BMPR1B
CHRM5
HOXC8
MAP3K7
MAPK6
RNF111
RPS6KA5
RUNX2
SMAD1
SMAD7
SMURF1
SMURF2
STAMBP
STRAP
TAB1
TGFBR1
TOB1
188 interacting genes:
ADRM1
ANAPC5
ANKRD13A
ANKRD13D
ANKRD50
ANKS4B
ANXA6
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASCC2
ASH2L
ATXN3
AVEN
AXIN1
BMPR2
BTK
BTRC
C9orf78
CALCOCO1
CCDC69
CCM2
CDC40
CDK14
CDKL1
CSNK1D
CSNK2A2
CTNNB1
CTNND1
CTTN
CUEDC1
CUL5
CXXC1
DDX54
DNAJC7
DUSP13B
DVL2
ECSIT
ELOF1
ELP3
ENTR1
EPHA1
EPN1
ETV6
FAF2
FBXL15
FBXO3
FBXO30
FCHO1
FES
FGF12
FGR
FKBP3
FSCN1
FZR1
GNG11
GRIPAP1
GRK3
HDGFL3
HIP1
HOMER2
ILRUN
IMPACT
ING2
INPP5B
IRAK2
ITGB1BP1
ITK
JUNB
KRT36
LATS1
LCK
LHX9
LIMS1
LMNA
LONRF3
MAP3K10
MAP3K2
MAP3K3
MAP3K9
MAP4K5
MARK2
MATK
MINDY3
MSN
NAA16
NDFIP2
NEDD8
NEK2
ODF2
OTUD6B
OXSR1
PADI4
PAK1
PAK1IP1
PDGFRA
PDLIM7
PICALM
PIP5K1C
PLEKHO1
POLR2A
PRKCA
PRKCG
PRKCI
PRR16
PSMD4
PSME3
PTEN
PWP1
RABEP1
RAD23A
RASD2
RBCK1
RHOA
RHOB
RHPN2
RIOK3
RIPK2
RIT1
RNF11
RNF114
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SCYL1
SENP8
SF3A1
SKIC8
SLAIN2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SQSTM1
SRSF4
SRSF5
STK31
STK35
STRAP
STUB1
TAB1
TAOK3
TAPT1
TBK1
TLN1
TNIK
TNIP2
TNK2
TNNT1
TOM1
TOM1L2
TRAF4
TRIP10
TTC17
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2K
UBE2L3
UBE2M
UBE2V1
UBQLN1
UBQLN2
UBTF
UBXN1
UBXN6
UBXN7
USP45
USP9X
WEE1
WFS1
XPO1
ZFAND5
Entrez ID
4091
57154
HPRD ID
04240
06902
Ensembl ID
ENSG00000137834
ENSG00000198742
Uniprot IDs
O43541
Q9HCE7
PDB IDs
2LAZ
2LB0
2LB1
2LTX
3PYC
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
SMAD Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
I-SMAD Binding
Regulation Of Cartilage Development
Positive Regulation Of Cartilage Development
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Chondrocyte Differentiation
Negative Regulation Of BMP Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
BMP Signaling Pathway
SMAD Protein Signal Transduction
Osteoblast Fate Commitment
Regulation Of Signaling
Negative Regulation Of Signal Transduction
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Signal Transduction
Negative Regulation Of Chondrocyte Proliferation
Transforming Growth Factor Beta Receptor Activity, Type I
Regulation Of BMP Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Activin Receptor Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Multicellular Organismal Process
Regulation Of Cell Communication
Positive Regulation Of Developmental Process
Regulation Of Osteoblast Differentiation
Protein Kinase Activity
Transferase Activity
Heteromeric SMAD Protein Complex
Positive Regulation Of CGAS/STING Signaling Pathway
Regulation Of Signal Transduction
Protein-containing Complex
Regulation Of Metabolic Process
Response To Growth Factor
Intracellular Signal Transduction
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Macromolecule Metabolic Process
Protein Phosphorylation
Regulation Of Primary Metabolic Process
Cytosol
Protein Kinase Activity
Modification-dependent Protein Catabolic Process
Protein Modification Process
Cytoplasm
Proteolysis Involved In Protein Catabolic Process
Kinase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Metabolic Process
Protein Serine/threonine Kinase Activity
Intracellular Signal Transduction
Intracellular Signaling Cassette
Macromolecule Catabolic Process
Protein Serine Kinase Activity
Proteolysis
Post-translational Protein Modification
Proteasomal Protein Catabolic Process
ATP Binding
Nucleus
Regulation Of Proteasomal Protein Catabolic Process
I-SMAD Binding
Nucleotide Binding
Macromolecule Metabolic Process
Signal Transduction
Regulation Of Proteolysis
Protein Ubiquitination
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Transferase Activity
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Nucleoplasm
Protein Modification By Small Protein Conjugation
Protein Phosphorylation
Heteromeric SMAD Protein Complex
Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Catabolic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Ubiquitin Binding
Regulation Of Cell Communication
Protein Polyubiquitination
Regulation Of Cellular Component Organization
Regulation Of Signaling
Regulation Of Protein Ubiquitination
Polyubiquitin Modification-dependent Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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