SMAD6 and MAP3K7

Number of citations of the paper that reports this interaction (PubMedID 10748100)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		SMAD6	MAP3K7
Description		SMAD family member 6	mitogen-activated protein kinase kinase kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Cilium Nuclear Body Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane ATAC Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Activin Receptor Binding Type I Activin Receptor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Kinase Activity Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Kinase Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Linear Polyubiquitin Binding
	Biological Process	Ureteric Bud Development Outflow Tract Septum Morphogenesis Heart Valve Development Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Negative Regulation Of Activin Receptor Signaling Pathway Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Coronary Vasculature Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of MiRNA Transcription	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Remodeling Apoptotic Process Inflammatory Response Immune Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interleukin-2 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway Defense Response To Bacterium Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Cell Size T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Angiotensin
Pathways		Signaling by BMP RUNX2 regulates bone development	Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 29273806 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 29273806 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Cortical surface area ( 32963231) Cortical volume ( 32963231) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		17 interacting genes: BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1	73 interacting genes: AKTIP BBS10 BCL10 CALML6 CAMK2G CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IL17RD IRAK1 MAILR MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB SUPT20H TAB1 TAB2 TGFBR1 TNFAIP8L2 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC USP29 USP4 USP8 VRK2 XIAP ZNF593 ZNF746
Entrez ID		4091	6885
HPRD ID		04240	04011
Ensembl ID		ENSG00000137834	ENSG00000135341
Uniprot IDs		O43541	O43318
PDB IDs			2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N 7NTH 7NTI 8GW3 9FPD
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process BMP Signaling Pathway SMAD Protein Signal Transduction Osteoblast Fate Commitment Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Activin Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Protein Kinase Activity Transferase Activity Heteromeric SMAD Protein Complex Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction Protein-containing Complex Regulation Of Metabolic Process Response To Growth Factor Intracellular Signal Transduction Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process	Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Signal Transduction Innate Immune Response-activating Signaling Pathway Protein Kinase Activity Regulation Of Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Non-canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Protein Modification Process Regulation Of Defense Response Negative Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Innate Immune Response Response To Stress Regulation Of MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasm Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Immune Response Regulation Of DNA-binding Transcription Factor Activity Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Immune Response-regulating Signaling Pathway Cytosol Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Regulation Of Immune System Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Transferase Activity
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