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SMAD6 and STRAP
Number of citations of the paper that reports this interaction (PubMedID
10757800
)
54
Data Source:
HPRD
(in vitro, in vivo)
SMAD6
STRAP
Description
SMAD family member 6
serine/threonine kinase receptor associated protein
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Golgi Apparatus
Cytosol
Cilium
Nuclear Body
Protein-containing Complex
Ciliary Basal Body
Heteromeric SMAD Protein Complex
Nucleus
Cytoplasm
Cytosol
SMN Complex
SMN-Sm Protein Complex
Molecular Function
Transcription Cis-regulatory Region Binding
Chromatin Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Activin Receptor Binding
Type I Activin Receptor Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
RNA Binding
MRNA Binding
Signaling Receptor Binding
Protein Binding
U2 SnRNP Binding
Biological Process
Ureteric Bud Development
Outflow Tract Septum Morphogenesis
Heart Valve Development
Aortic Valve Morphogenesis
Mitral Valve Morphogenesis
Pulmonary Valve Morphogenesis
Ventricular Septum Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Immune Response
Zygotic Specification Of Dorsal/ventral Axis
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Cell Differentiation
Negative Regulation Of Ossification
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Cell-substrate Adhesion
Response To Lipopolysaccharide
Negative Regulation Of Activin Receptor Signaling Pathway
Response To Laminar Fluid Shear Stress
Aorta Development
Negative Regulation Of Apoptotic Process
Response To Estrogen
Fat Cell Differentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Coronary Vasculature Development
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Alternative MRNA Splicing, Via Spliceosome
Spliceosomal SnRNP Assembly
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Splicing
Protein-RNA Complex Assembly
Neuron Differentiation
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways
Signaling by BMP
RUNX2 regulates bone development
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Positive Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Carpal tunnel syndrome (
30833571
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Glaucoma (primary open-angle) (
33627673
)
Height (
31562340
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Hip circumference adjusted for BMI (
34021172
)
Lung cancer (smoking interaction) (
24658283
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Refractive error (
32231278
)
Severe aortic features in Marfan syndrome (
30087447
)
Subcutaneous adipose tissue (
22589738
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Interacting Genes
17 interacting genes:
BMPR1B
CHRM5
HOXC8
MAP3K7
MAPK6
RNF111
RPS6KA5
RUNX2
SMAD1
SMAD7
SMURF1
SMURF2
STAMBP
STRAP
TAB1
TGFBR1
TOB1
31 interacting genes:
ANXA1
CEBPA
CHEK2
FOXP1
GEMIN6
GEMIN7
MAP1B
MTRES1
NEIL3
NXF1
PBLD
PDPK1
PTEN
RN7SL1
RNU1-1
RNU2-1
SMAD2
SMAD3
SMAD6
SMAD7
SMN1
SMURF1
SNRPB
SNRPD2
SNRPD3
SNRPE
SUMO2
SUMO4
SZRD1
TGFBR1
TGFBR2
Entrez ID
4091
11171
HPRD ID
04240
05816
Ensembl ID
ENSG00000137834
ENSG00000023734
Uniprot IDs
O43541
Q9Y3F4
PDB IDs
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
SMAD Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
I-SMAD Binding
Regulation Of Cartilage Development
Positive Regulation Of Cartilage Development
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Chondrocyte Differentiation
Negative Regulation Of BMP Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
BMP Signaling Pathway
SMAD Protein Signal Transduction
Osteoblast Fate Commitment
Regulation Of Signaling
Negative Regulation Of Signal Transduction
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Signal Transduction
Negative Regulation Of Chondrocyte Proliferation
Transforming Growth Factor Beta Receptor Activity, Type I
Regulation Of BMP Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Activin Receptor Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Multicellular Organismal Process
Regulation Of Cell Communication
Positive Regulation Of Developmental Process
Regulation Of Osteoblast Differentiation
Protein Kinase Activity
Transferase Activity
Heteromeric SMAD Protein Complex
Positive Regulation Of CGAS/STING Signaling Pathway
Regulation Of Signal Transduction
Protein-containing Complex
Regulation Of Metabolic Process
Response To Growth Factor
Intracellular Signal Transduction
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Macromolecule Metabolic Process
Protein Phosphorylation
Regulation Of Primary Metabolic Process
SMN-Sm Protein Complex
I-SMAD Binding
Spliceosomal SnRNP Assembly
Spliceosomal Complex Assembly
Heteromeric SMAD Protein Complex
7-methylguanosine Cap Hypermethylation
SMAD Protein Signal Transduction
U2 SnRNP
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Protein-RNA Complex Assembly
Type I Transforming Growth Factor Beta Receptor Binding
U4 SnRNP
Response To Growth Factor
Methylosome
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Small Nuclear Ribonucleoprotein Complex
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
U1 SnRNP
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
U5 SnRNP
Regulation Of Epithelial To Mesenchymal Transition
RNA Splicing, Via Transesterification Reactions
Activin Receptor Binding
U2-type Prespliceosome Assembly
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Nucleoplasm
R-SMAD Binding
Regulation Of SMAD Protein Signal Transduction
Trophoblast Cell Migration
U7 SnRNP
U2-type Spliceosomal Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
U2-type Catalytic Step 2 Spliceosome
U4/U6 X U5 Tri-snRNP Complex
Ureteric Bud Development
SMN Complex
Ubiquitin Protein Ligase Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Ossification
Co-SMAD Binding
Gemini Of Cajal Bodies
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
MRNA Splicing, Via Spliceosome
Mesonephric Tubule Development
Mesonephric Epithelium Development
SMAD Binding
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Tagcloud (Intersection)
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