MAPRE1 and KLHL21

Number of citations of the paper that reports this interaction (PubMedID 27641145)
43

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MAPRE1	KLHL21
Description		microtubule associated protein RP/EB family member 1	kelch like family member 21
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Cell Projection Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Astral Microtubule End Mitotic Spindle Microtubule	Cytoplasm Spindle Polar Microtubule Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Intracellular Protein Localization Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Protein Localization To Mitotic Spindle Protein Localization To Astral Microtubule Non-motile Cilium Assembly	Protein Ubiquitination Regulation Of Cytokinesis Chromosome Passenger Complex Localization To Spindle Midzone Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Appendicular lean mass ( 33097823)
Interacting Genes		50 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TUBA1A TUBB ZNF653	5 interacting genes: AURKB CYLD IKBKB KLC3 MAPRE1
Entrez ID		22919	9903
HPRD ID		04379	17239
Ensembl ID		ENSG00000101367	ENSG00000162413
Uniprot IDs		Q15691	Q9UJP4
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Cytoskeleton Organization Regulation Of Cell Cycle Microtubule-based Process Establishment Of Mitotic Spindle Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoplasm Microtubule Cytoskeleton Regulation Of Organelle Organization Establishment Of Organelle Localization Organelle Localization Mitotic Spindle Microtubule Plus-end Positive Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Establishment Of Spindle Localization Kinetochore Spindle Localization Centrosome Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Microtubule Binding Cellular Component Assembly Regulation Of Microtubule Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Cytosol Establishment Of Localization In Cell Establishment Of Spindle Orientation Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Metabolic Process Microtubule Plus-end Binding Spindle Perinuclear Region Of Cytoplasm Protein Kinase Binding Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Macromolecule Metabolic Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Pattern Recognition Receptor Signaling Pathway Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Intracellular Receptor Signaling Pathway Activation Of Innate Immune Response Spindle Midzone Regulation Of Microtubule-based Process Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Innate Immune Response Microtubule Immune Response-activating Signaling Pathway Cytoplasmic Microtubule Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Defense Response Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Cytoskeleton Organization Met1-linked Polyubiquitin Deubiquitinase Activity Cytoskeleton Spindle Assembly Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Astral Microtubule Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Immune Response Centrosome Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Microtubule Cytoskeleton Organization Involved In Mitosis Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Protein Linear Deubiquitination Negative Regulation Of Intracellular Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent IkappaB Kinase Activity Spindle Pole Mitotic Spindle Astral Microtubule End Cortical Microtubule Cytoskeleton Spindle Organization Microtubule-based Process
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