MAPRE1 and CLASP1

Number of citations of the paper that reports this interaction (PMID 15631994)
101

Data Source:
HPRD (in vivo, in vitro)

		MAPRE1	CLASP1
Gene Name		microtubule-associated protein, RP/EB family, member 1	cytoplasmic linker associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Microtubule Cytoplasmic Microtubule Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end	Kinetochore Condensed Chromosome Kinetochore Golgi Apparatus Centrosome Kinetochore Microtubule Cytosol Spindle Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Poly(A) RNA Binding Microtubule Plus-end Binding	Protein Binding Microtubule Binding Kinetochore Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Cell Proliferation Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Cell Division Positive Regulation Of Microtubule Plus-end Binding	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Bundle Formation Organelle Organization Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Establishment Or Maintenance Of Cell Polarity Axon Guidance Exit From Mitosis Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Anchoring Establishment Of Spindle Orientation Cell Division
Pathways		Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes	Role of Abl in Robo-Slit signaling Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Signaling by Robo receptor Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ABCB1 APC APC2 APP AURKB BCL3 CDK5RAP2 CLASP1 CLASP2 CLIP1 COPS5 COPS8 CSN3 CYLD DCTN1 HSPA1A IKBKG KAT2B KAT5 KIF2C LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PDE4DIP PIK3R4 POLE2 PQBP1 PSMA1 SPDYE2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB	5 interactors: CLIP2 JAKMIP2 MAPRE1 MAPRE3 YWHAG
Entrez ID		22919	23332
HPRD ID		04379	09322
Ensembl ID		ENSG00000101367	ENSG00000074054
Uniprot IDs		B4DM33 Q15691	A2RU21 B7ZLX3 Q7Z460
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3TQ7	4K92
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Microtubule-based Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Microtubule-based Process Response To Stimulus Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Chromosome Segregation Cullin Deneddylation Cellular Localization Regulation Of Wnt Signaling Pathway Establishment Or Maintenance Of Cell Polarity Response To Radiation Protein Deneddylation Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Component Assembly Spindle Checkpoint Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Microtubule Bundle Formation Response To Light Stimulus Cellular Protein Complex Assembly Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Transferase Activity	Positive Regulation Of Microtubule Plus-end Binding Positive Regulation Of Protein Binding Mitotic Cell Cycle Process Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Binding Cell Cycle Process Regulation Of Protein Binding Cell Cycle Regulation Of Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Protein Localization To Microtubule Cell Division Negative Regulation Of Microtubule Polymerization Organelle Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Microtubule Polymerization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Mitochondrion Organization Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Cellular Protein Localization Negative Regulation Of Protein Polymerization Regulation Of Phosphorus Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?		akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant	clip1 cranial cytoskeleton ectoderm ectodermal embryogenesis gastrulation glued hemisphere involuting laevis lis1 maternally mesoderm microtubule microtubules movements nerves neurogenesis p150 persists platforms progresses stim1 tip tips tracking vertebrate xenopus
Tagcloud (Difference) ?		akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby trafficking tubulin variant	clip1 cranial cytoskeleton ectoderm ectodermal embryogenesis gastrulation glued hemisphere involuting laevis lis1 maternally mesoderm movements nerves neurogenesis p150 persists platforms progresses stim1 tip tips vertebrate xenopus
Tagcloud (Intersection) ?		microtubule microtubules tracking