SCIN and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 12438125)
0

Data Source:
HPRD (in vivo)

		SCIN	ACTC1
Description		scinderin	actin alpha cardiac muscle 1
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Cytoskeleton Brush Border Cell Cortex Actin Cytoskeleton Cell Projection Extracellular Exosome Anchoring Junction	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Phosphatidylserine Binding Actin Binding Calcium Ion Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Metal Ion Binding Actin Filament Binding	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding
	Biological Process	Central Nervous System Development Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Calcium-ion Regulated Exocytosis Cell Projection Assembly Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Secretion Positive Regulation Of Actin Nucleation Actin Filament Capping	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration
Pathways			Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Height ( 31562340) Metabolite levels ( 23823483) Small cell lung carcinoma ( 28604730)	Axial length ( 24144296) Refractive error ( 20835239 32231278)
Interacting Genes		3 interacting genes: ACTA1 ACTC1 ACTG1	43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		85477	70
HPRD ID		11539	00015
Ensembl ID		ENSG00000006747	ENSG00000159251
Uniprot IDs		Q9Y6U3	B3KPP5 P68032
PDB IDs		3FG6 5A1K 5A1M	8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R
Enriched GO Terms of Interacting Partners?		Actin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Blood Microparticle Myosin Binding Actin Cytoskeleton Sarcomere Filopodium Cell Body Structural Constituent Of Cytoskeleton Basal Body Patch Actomyosin Structure Organization Lamellipodium Muscle Contraction Regulation Of Transepithelial Transport Muscle System Process Actin Filament Organization Positive Regulation Of Gene Expression Cytoplasmic Actin-based Contraction Involved In Cell Motility Protein Localization To Bicellular Tight Junction Dense Body Morphogenesis Of A Polarized Epithelium Membraneless Organelle Assembly Structural Constituent Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Stress Granule Assembly ATP Binding Striated Muscle Thin Filament Cytoskeleton Extracellular Space Profilin Binding Actin Cytoskeleton Organization Regulation Of Stress Granule Assembly Hydrolase Activity Actin Filament-based Process Tissue Morphogenesis Focal Adhesion Cardiac Myofibril Assembly Nucleotide Binding Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding Protein Localization To Cell-cell Junction Calyx Of Held Supramolecular Fiber Organization Multicellular Organismal-level Homeostasis Postsynaptic Cytoskeleton Organization Heart Contraction Regulation Of Synaptic Vesicle Endocytosis Skeletal Muscle Fiber Development Extracellular Exosome Myofibril Assembly	Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization
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