SCIN and UBAP2L

Data Source: HiPPIP (Novel)

		SCIN	UBAP2L
Name		scinderin	ubiquitin associated protein 2 like
Structure			No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytoskeleton Brush Border Cell Cortex Actin Cytoskeleton Cell Projection Extracellular Exosome Anchoring Junction	Nucleus Chromosome Cytoplasm Cytoplasmic Stress Granule PcG Protein Complex
	Molecular Function	Phosphatidylserine Binding Actin Binding Calcium Ion Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Metal Ion Binding Actin Filament Binding	RNA Binding Protein Binding
	Biological Process	Central Nervous System Development Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Calcium-ion Regulated Exocytosis Cell Projection Assembly Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Secretion Positive Regulation Of Actin Nucleation Actin Filament Capping	Binding Of Sperm To Zona Pellucida Stress Granule Assembly Hematopoietic Stem Cell Homeostasis Positive Regulation Of Stress Granule Assembly
GWAS		Height ( 31562340 ) Metabolite levels ( 23823483 ) Small cell lung carcinoma ( 28604730 )	Bipolar disorder ( 31043756 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30224653 ) Fish- and plant-related diet ( 32066663 ) Smoking initiation ( 30617275 33082346 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		1 novel interactors: UBAP2L	9 novel interactors: AGO2 CHTOP HAX1 KCNN3 POGZ SCIN SLC27A3 SMCP TCHH
Interacting Genes		3 interacting genes: ACTA1 ACTC1 ACTG1	12 interacting genes: ATXN1 FXR1 G3BP1 ITCH LINC00624 MTNR1A MTNR1B NEDD4 PLXNA2 PRRC2A SUMO2 ZP3
Entrez ID		85477	9898
HPRD ID		11539	06665
Ensembl ID		ENSG00000006747	ENSG00000143569
Uniprot IDs		Q9Y6U3	A0AA34QVE6 B4DYY5 F8W726 Q14157
PDB IDs		3FG6 5A1K 5A1M	Not available
GO Terms Enriched among Interactors		Actin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Blood Microparticle Myosin Binding Actin Cytoskeleton Sarcomere Filopodium Cell Body Structural Constituent Of Cytoskeleton Basal Body Patch Actomyosin Structure Organization Lamellipodium Muscle Contraction Regulation Of Transepithelial Transport Muscle System Process Actin Filament Organization Positive Regulation Of Gene Expression Cytoplasmic Actin-based Contraction Involved In Cell Motility Protein Localization To Bicellular Tight Junction Dense Body Morphogenesis Of A Polarized Epithelium Membraneless Organelle Assembly Structural Constituent Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Stress Granule Assembly ATP Binding Striated Muscle Thin Filament Cytoskeleton Extracellular Space Profilin Binding Actin Cytoskeleton Organization Regulation Of Stress Granule Assembly Hydrolase Activity Actin Filament-based Process Tissue Morphogenesis Focal Adhesion Cardiac Myofibril Assembly Nucleotide Binding Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding Protein Localization To Cell-cell Junction Calyx Of Held Supramolecular Fiber Organization Multicellular Organismal-level Homeostasis Postsynaptic Cytoskeleton Organization Heart Contraction Regulation Of Synaptic Vesicle Endocytosis Skeletal Muscle Fiber Development Extracellular Exosome Myofibril Assembly	Melatonin Receptor Activity Cell Cortex