COPS3 and COPS8

Number of citations of the paper that reports this interaction (PubMedID 11285227)
43

Data Source:
HPRD (in vitro)

		COPS3	COPS8
Description		COP9 signalosome subunit 3	COP9 signalosome subunit 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation	Protein Deneddylation Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)	Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC	17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 UBC USHBP1
Entrez ID		8533	10920
HPRD ID		07262	16737
Ensembl ID		ENSG00000141030	ENSG00000198612
Uniprot IDs		B4DN01 Q9UNS2	Q99627
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Modification Process Cytosol Regulation Of Protein Modification Process Ubiquitin Protein Ligase Binding DeNEDDylase Activity Ubiquitin Ligase Complex Scaffold Activity Protein Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of T Cell Apoptotic Process Eukaryotic Translation Initiation Factor 3 Complex Necroptotic Process Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Programmed Necrotic Cell Death T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Cytoplasm Response To Methotrexate Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of T Cell Apoptotic Process Sulfite Oxidase Activity Negative Regulation Of Helicase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1 To G0 Transition Protein Localization To Astral Microtubule Protein-containing Complex Leukocyte Apoptotic Process Translation Initiation Factor Activity Dihydrofolate Reductase Activity Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway
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