COPS3 and NABP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPS3	NABP1
Description		COP9 signalosome subunit 3	nucleic acid binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Site Of Double-strand Break SOSS Complex
	Molecular Function	Protein Binding	DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)	Colorectal cancer ( 23266556)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC	10 interacting genes: COPS3 KHDRBS2 MKRN3 PURB QKI RBMX REL TFCP2 TP53 TRIM7
Entrez ID		8533	64859
HPRD ID		07262	08009
Ensembl ID		ENSG00000141030	ENSG00000173559
Uniprot IDs		B4DN01 Q9UNS2	Q96AH0
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity	DNA-binding Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process MRNA Binding MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Processing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Splicing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Type I Interferon Production Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Internal N(7)-methylguanine-containing RNA Reader Activity MRNA Transcription Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process T Cell Activation Involved In Immune Response Mononuclear Cell Differentiation Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Myofibroblast Contraction Regulation Of MRNA Metabolic Process Negative Regulation Of MiRNA Catabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm DNA Binding Leukocyte Differentiation RNA Metabolic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Regulation Of MiRNA Metabolic Process Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Supraspliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?