COPS3 and KRT80

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPS3	KRT80
Description		COP9 signalosome subunit 3	keratin 80
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Intermediate Filament Desmosome Keratin Filament Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation	Keratinization Intermediate Filament Organization
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)	Cutaneous leishmaniasis ( 32830257) Diisocyanate-induced asthma ( 25918132) Telomere length ( 24465473)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC	22 interacting genes: AIRIM COPS3 GINS3 KRT14 KRT15 KRT16 KRT19 KRT20 KRT24 KRT25 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT38 LCA5L LMO2 MEOX2 UCHL5
Entrez ID		8533	144501
HPRD ID		07262	14068
Ensembl ID		ENSG00000141030	ENSG00000167767
Uniprot IDs		B4DN01 Q9UNS2	Q6KB66
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Anatomical Structure Morphogenesis Cytoskeleton Organelle Organization Hair Cycle Structural Constituent Of Cytoskeleton Cell Differentiation Epidermis Development Extracellular Exosome Cellular Developmental Process Cytosol Developmental Process Tissue Development Hair Follicle Morphogenesis Intermediate Filament Cytoskeleton Cornified Envelope Keratinocyte Differentiation Protein Binding Keratinization Terminal Web Hair Cycle Process
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