COPS3 and CUL5

Number of citations of the paper that reports this interaction (PMID 11337588)
171

Data Source:
HPRD (in vitro)

		COPS3	CUL5
Gene Name		COP9 signalosome subunit 3	cullin 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm COP9 Signalosome	Nucleus Cytosol Plasma Membrane Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Receptor Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Cullin Deneddylation	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Response To Osmotic Stress Cell Cycle Arrest Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Cytosolic Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways			Signaling by ERBB2 Vif-mediated degradation of APOBEC3G Antigen processing: Ubiquitination & Proteasome degradation HIV Infection Host Interactions of HIV factors Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARAF CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 GPS1 IKBKB IKBKG ITGB2 JUN LRP2BP MLF1 RAF1 TP53	33 interactors: ANAPC11 ARIH2 ASB11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D3 DCUN1D4 DCUN1D5 GOLGA2 GPS1 NEDD8 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RNF7 SMAD2 SMURF1 SOX30 TCEB1 TCEB2 TGFBR1 UBE2F VHL
Entrez ID		8533	8065
HPRD ID		07262	03444
Ensembl ID		ENSG00000141030	ENSG00000166266
Uniprot IDs		Q9UNS2	Q93034
PDB IDs			3DPL 3DQV 4JGH
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Apoptotic Process Response To External Stimulus Negative Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Activation Of Innate Immune Response Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Negative Regulation Of Cell Proliferation Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Phosphorylation Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade	Cullin Deneddylation Protein Deneddylation Cellular Protein Modification Process Protein Modification By Small Protein Removal Cellular Protein Metabolic Process Protein Neddylation Protein Modification By Small Protein Conjugation Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Catabolic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Proteolysis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cholesterol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Response To Hypoxia Activin Receptor Signaling Pathway Inactivation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Binding Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Positive Regulation Of Dense Core Granule Biogenesis Protein Polyubiquitination Positive Regulation Of Viral Transcription Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Proliferation
Tagcloud ?		arises arising bones ccnd1 cdk4 chromosomal chromosomes complement conventional cytogenetic decade demonstration derivative diploid homolog immunoreactivity loci locus malignancy mdm2 metaphysis monoallelic neoplastic neu osteosarcoma proximal rearrangements small tibia	293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice
Tagcloud (Difference) ?		arises arising bones ccnd1 cdk4 chromosomal chromosomes complement conventional cytogenetic decade demonstration derivative diploid homolog immunoreactivity loci locus malignancy mdm2 metaphysis monoallelic neoplastic neu osteosarcoma proximal rearrangements small tibia	293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice
Tagcloud (Intersection) ?