COPS3 and PRXL2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPS3	PRXL2B
Description		COP9 signalosome subunit 3	peroxiredoxin like 2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Myelin Sheath Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Prostaglandin F Synthase Activity
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC	4 interacting genes: COPS3 PDPK1 TCP11L1 TNFSF11
Entrez ID		8533	127281
HPRD ID		07262	14513
Ensembl ID		ENSG00000141030	ENSG00000157870
Uniprot IDs		B4DN01 Q9UNS2	A0A0A0MRV4 A0A0A0MT35 A0A2P0CTB1 A0A2P0CU24 J3KPF5 Q8TBF2
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity	Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion 3-phosphoinositide-dependent Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium-mediated Signaling Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Phospholipase Activator Activity Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type B Pancreatic Cell Development Positive Regulation Of Cell Activation Regulation Of Canonical NF-kappaB Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Protein Deneddylation Tooth Eruption Positive Regulation Of Osteoclast Development Positive Regulation Of Bone Resorption Positive Regulation Of Fever Generation Osteoclast Development Positive Regulation Of Heat Generation Regulation Of Osteoclast Development Osteoclast Proliferation Paracrine Signaling Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Regulation Of Corticotropin-releasing Hormone Secretion Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Corticotropin-releasing Hormone Secretion Regulation Of Fever Generation Vascular Endothelial Cell Response To Fluid Shear Stress Signal Transduction Positive Regulation Of Icosanoid Secretion Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Cell Adhesion Negative Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Phospholipase Binding Cellular Response To Laminar Fluid Shear Stress Response To Laminar Fluid Shear Stress Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Protein Neddylation Protein Neddylation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Fatty Acid Transport Regulation Of Lymphocyte Activation Monocyte Chemotaxis
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