COPS3 and LRP2BP

Number of citations of the paper that reports this interaction (PubMedID 12508107)
0

Data Source:
HPRD (two hybrid)

		COPS3	LRP2BP
Description		COP9 signalosome subunit 3	LRP2 binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)	Systemic sclerosis ( 33069728)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC	25 interacting genes: ADGRB2 C1orf50 CCDC24 CDKL3 CDKN1A COPS3 DTX2 FAAP20 FAM90A1 GAS2L2 GEM GPKOW GSTP1 HOXC8 LENG1 LRP2 P4HA3 PICK1 RAB33A RBM4 SCNM1 SMARCC1 SNW1 TSC22D4 ZNF587
Entrez ID		8533	55805
HPRD ID		07262	10911
Ensembl ID		ENSG00000141030	ENSG00000109771
Uniprot IDs		B4DN01 Q9UNS2	Q9P2M1
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity	Cellular Response To Cell-matrix Adhesion
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